MALIGNANT TRANSFORMATION AND LIFE EXPECTANCY IN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
MALIGNANT TRANSFORMATION AND LIFE EXPECTANCY IN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
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DOI：
10.1111/j.1365-2141.1992.tb08245.x
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发表时间：
1992-07-01
影响因子：
6.5
通讯作者：
MONTSERRAT, E
中科院分区：
文献类型：
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作者：
BLADE, J;LOPEZGUILLERMO, A;MONTSERRAT, E
在20年的时间里，我们分析了128名诊断为未确定意义单克隆伽玛病（MGUS）的患者中恶性转化的精算概率和对预期生存的影响。在56个月的中位随访中，101例（78.9%）患者的m成分保持稳定，14例（10.9%）患者死于非相关疾病，13例（10.2%）患者发生MGUS恶性转化（多发性骨髓瘤，10例，原发性淀粉样变性，2例，Waldenstrom巨球蛋白血症，1例）。5年和10年恶性转化的精算概率分别为8.5%和19.2%。当分析不同的表现特征对恶性转化的预测价值时，MGUS的IgA类型是唯一与恶性转化事件较高概率相关的变量(P
The actuarial probability of malignant transformation and the impact on expected survival were analysed in a series of 128 persons diagnosed with monoclonal gammopathy of undetermined significance (MGUS) over a 20-year period. At a median follow-up of 56 months the M-component remains stable in 101 patients (78.9%), 14 patients (10.9%) have died from non-related disorders and 13 (10.2%) have developed malignant transformation of MGUS (multiple myeloma, 10, primary amyloidosis, two, Waldenstrom's macroglobulinaemia, one). The actuarial probability of malignant transformation at 5 and 10 years was 8.5% and 19.2%, respectively. When different presenting features were analysed for predictive value of the malignant transformation, the IgA type of MGUS was the only variable associated with a higher probability of such an event (P