Three-Component, Diastereoselective Synthesis of Highly Functionalized Indane Derivatives Based on an Anionic Domino Sequence from α-Nitroketones
Three-Component, Diastereoselective Synthesis of Highly Functionalized Indane Derivatives Based on an Anionic Domino Sequence from α-Nitroketones
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DOI：
10.1055/s-0030-1258048
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发表时间：
2010-10-01
期刊：
影响因子：
2
通讯作者：
Carlos Menendez, J.
中科院分区：
文献类型：
--
作者：
Giorgi, Giorgio;Arroyo, Francisco J.;Carlos Menendez, J.
在DBU存在下，以四氢呋喃和水为溶剂，七元或八元环状α-硝基酮和芳香族1，2-二醛反应，一锅法，非对映选择性地合成了具有三个相邻立构中心的2-硝基茚满-1，2-二醇，其中一个为季中心。
The reaction between seven- or eight-membered cyclic alpha-nitroketones and aromatic 1,2-dialdehydes in the presence of DBU, with tetrahydrofuran containing some water as solvent, afforded 2-nitroindane-1,2-diols with three contiguous stereocenters, one of which is quaternary, in a one-pot, diastereoselective fashion.