Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4
Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4
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DOI：
10.1159/000134621
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发表时间：
1997-01-01
期刊：
影响因子：
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通讯作者：
Sylla, BS
中科院分区：
文献类型：
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作者：
Lamartine, J;Seri, M;Sylla, BS
我们已经确定了一个新的人类基因与小鼠Pa 2g 4细胞周期基因具有很强的同源性。该新基因（PA 2G 4）属于一个基因家族，其成员分布在染色体3q 24-q25、6 q22、9 q21、12 q13、18 q12、20 p12和Xq 25等区域。分离到一个1697个核苷酸的复合cDNA。该cDNA的序列预测了394个氨基酸的蛋白质。该人蛋白的推导的氨基酸序列显示与小鼠蛋白p38- 2G 4非常强的同源性。分析的cDNA可能对应于在12 q13发现的功能拷贝。
We have identified a novel human gene with strong homology to the mouse Pa2g4 cell cycle gene. This novel gene (called PA2G4) belongs to a gene family with members in several chromosome regions: 3q24-q25, 6q22, 9q21, 12q13, 18q12, 20p12 and Xq25. A composite cDNA of 1697 nucleotides was isolated. The sequence of this cDNA predicts a protein of 394 amino acids. The deduced amino acid sequence of this human protein shows very strong homology to the mouse protein p38-2G4. The cDNA analyzed probably corresponds to a functional copy found at 12q13.