Associations of hypertensive disorders of pregnancy and gestational diabetes mellitus with menopausal symptoms at midlife in Project Viva.
Associations of hypertensive disorders of pregnancy and gestational diabetes mellitus with menopausal symptoms at midlife in Project Viva.
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Viva Project Project Life的怀孕和妊娠糖尿病与绝经症状的高血压疾病与绝经症状的关联。
DOI：
10.1097/gme.0000000000002014
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发表时间：
2022-09-01
影响因子：
2.7
通讯作者：
Chavarro, Jorge E.
中科院分区：
文献类型：
--
作者：
Soria-Contreras, Diana C.;Perng, Wei;Rifas-Shiman, Sheryl L.;Minguez-Alarcon, Lidia;Hivert, Marie-France;Shifren, Jan;Oken, Emily;Chavarro, Jorge E.
关键词：
评估妊娠期高血压疾病（HDP）和妊娠期糖尿病（GDM）终生史与中年绝经期症状的关系。对参与Viva项目（妊娠期间入组的持续队列）的女性进行的次要分析。暴露是HDP或GDM的终生史，通过审查门诊和医院病历评估首次妊娠，通过研究入组（1999-2002）和中年访视（2017-2021）时的访谈或问卷评估所有其他妊娠。主要结局是中年研究访视时应用的绝经评定量表（MRS）。我们使用线性或逻辑回归模型调整协变量，如基线年龄，种族/民族，教育，已婚/同居，家庭收入，基线产次，初潮年龄和中年体重指数。在纳入的676名参与者中，120名（18%）有HDP病史，47名（7%）有GDM病史。中年访视时的平均（SD）年龄为52（3.9）岁，48%的参与者经历过更年期。有HDP或GDM病史的女性在总症状、领域特异性或个体症状方面没有一致的差异。HDP和/或GDM的病史与自然绝经开始时的年龄无关。我们的研究结果不支持HDP或GDM病史与绝经期症状的严重程度或自然绝经期开始时的年龄相关。需要对有这些妊娠并发症病史的妇女进行更大规模的研究，以澄清它们与更年期症状的关系。
To evaluate the associations of a lifetime history of hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) with menopausal symptoms in midlife. Secondary analysis of women participating in Project Viva, an ongoing cohort enrolled during pregnancy. The exposure was lifetime history of HDP or GDM assessed for the index pregnancy by review of outpatient and hospital medical records and for all other pregnancies by interview or questionnaire at study entry (1999-2002) and the midlife visit (2017-2021). The primary outcome was the Menopause Rating Scale (MRS) applied at the midlife study visit. We used linear or logistic regression models adjusted for covariates such as baseline age, race/ethnicity, education, married/cohabiting, household income, baseline parity, age at menarche, and body mass index at midlife. Of the 676 included participants, 120 (18%) had history of HDP, and 47 (7%) had history of GDM. The mean (SD) age was 52 (3.9) years at the midlife visit, and 48% of the participants had experienced menopause. There were no consistent differences in total symptoms, domain-specific or individual symptoms in women with history of HDP or GDM. A history of HDP and/or GDM was not associated with age at the onset of natural menopause. Our findings do not support an association of a history of HDP or GDM with the severity of menopausal symptoms or age at the onset of natural menopause. Larger studies of women with history of these pregnancy complications are needed to clarify their association with menopausal symptoms.