Contributions of White Matter Connectivity and BOLD Modulation to Cognitive Aging: A Lifespan Structure-Function Association Study.
Contributions of White Matter Connectivity and BOLD Modulation to Cognitive Aging: A Lifespan Structure-Function Association Study.
复制标题
白质连接和 BOLD 调节对认知衰老的贡献：寿命结构-功能关联研究。
DOI：
10.1093/cercor/bhz193
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Kennedy,KristenM
中科院分区：
文献类型：
--
作者：
Webb,ChristinaE;Rodrigue,KarenM;Hoagey,DavidA;Foster,ChrisM;Kennedy,KristenM
随着年龄的增长，灵活调节大脑激活以增加认知挑战的能力会下降。这种与年龄相关的区域灰质功能动态范围的减少可能部分是由于区域白色物质束的年龄相关性退化。在这里，171名健康成年人（年龄在20-94岁之间）的寿命样本接受了磁共振成像（MRI）扫描，包括弥散加权成像（用于纤维束成像）和功能成像（数字化任务）。我们利用结构方程模型来检验这一假设，即年龄相关的递减在白色物质的微观结构与改变血氧水平依赖（BOLD）调制，并反过来，都与扫描任务的准确性和执行功能的性能。指定的结构方程模型证明了良好的拟合，表明增加年龄的负面影响的sn-back任务的准确性和执行功能的性能，部分原因是由于退化的白色物质束微观结构和减少任务难度相关的BOLD调制。我们进一步证明，较差的白色物质微结构完整性与减弱的BOLD调制相关，特别是在显示正调制效应的区域，而不是负调制效应。这项结构-功能关联研究提供了进一步的证据，表明结构连接影响功能激活，这两种机制串联预测认知性能，无论是在任务期间，还是在扫描仪环境之外测量的认知。
The ability to flexibly modulate brain activation to increasing cognitive challenge decreases with aging. This age-related decrease in dynamic range of function of regional gray matter may be, in part, due to age-related degradation of regional white matter tracts. Here, a lifespan sample of 171 healthy adults (aged 20–94) underwent magnetic resonance imaging (MRI) scanning including diffusion-weighted imaging (for tractography) and functional imaging (a digitn-back task). We utilized structural equation modeling to test the hypothesis that age-related decrements in white matter microstructure are associated with altered blood-oxygen-level-dependent (BOLD) modulation, and both in turn, are associated with scanner-task accuracy and executive function performance. Specified structural equation model evidenced good fit, demonstrating that increased age negatively affectsn-back task accuracy and executive function performance in part due to both degraded white matter tract microstructure and reduced task-difficulty-related BOLD modulation. We further demonstrated that poorer white matter microstructure integrity was associated with weakened BOLD modulation, particularly in regions showing positive modulation effects, as opposed to negative modulation effects. This structure-function association study provides further evidence that structural connectivity influences functional activation, and the two mechanisms in tandem are predictive of cognitive performance, both during the task, and for cognition measured outside the scanner environment.