Mothers' anxiety during pregnancy is associated with asthma in their children.
Mothers' anxiety during pregnancy is associated with asthma in their children.
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DOI：
10.1016/j.jaci.2009.01.042
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发表时间：
2009-04
影响因子：
14.2
通讯作者：
Henderson, A. John
中科院分区：
文献类型：
--
作者：
Cookson, Hannah;Granell, Raquel;Joinson, Carol;Ben-Shlomo, Yoav;Henderson, A. John
早年母亲的压力与儿童哮喘的发生有关，尽管尚不清楚是否存在任何暴露的关键时期。哮喘与产前母亲压力的关系尚未见报道。我们测试了孕妇产前和产后的焦虑和/或抑郁是否可以预测其后代在儿童时期患哮喘的风险。雅芳父母和儿童纵向研究是在怀孕期间招募的基于人群的出生队列。我们提供了 5810 名儿童 7.5 岁时母亲焦虑评分和哮喘的数据。使用经过验证的 Crown-Crisp 体验指数在妊娠 18 周和 32 周评估焦虑情况。哮喘在 7.5 岁时被定义为医生诊断出的哮喘，且目前有症状或在过去 12 个月内接受过治疗。使用多变量逻辑回归来确定产前焦虑与哮喘的关联（比值比；95% CI）。独立于产后焦虑并调整了一些可能的混杂因素，与妊娠 32 周时焦虑评分最低四分位数的母亲相比，母亲在 7.5 岁时患哮喘的可能性更高（比值比为 1.64；95% CI，1.25-2.17），有证据表明存在剂量反应（趋势 P 值<0.001）。母亲的焦虑症状作为胎儿时期压力的指标，可能会导致儿童期哮喘的发生。
Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure. The association of asthma with prenatal exposure to maternal stress has not been reported. We tested whether prenatal and postnatal anxiety and/or depression in pregnant women predicted the risk of their offspring developing asthma in childhood. The Avon Longitudinal Study of Parents and Children is a population-based birth cohort recruited during pregnancy. Data were available on maternal anxiety scores and asthma at age 7½ years in 5810 children. Anxiety was assessed at 18 and 32 weeks of gestation by using the validated Crown-Crisp Experiential Index. Asthma was defined at age 7½ years as doctor-diagnosed asthma with current symptoms or treatment in the previous 12 months. Multivariable logistic regression was used to determine the association of prenatal anxiety with asthma (odds ratio; 95% CI). Independent of postnatal anxiety and adjusted for a number of likely confounders, there was a higher likelihood of asthma at age 7½ years (odds ratio, 1.64; 95% CI, 1.25-2.17) in children of mothers in the highest compared with lowest quartile of anxiety scores at 32 weeks of gestation, with evidence for a dose-response (P value for trend <0.001). Maternal anxiety symptoms as an indicator of stress during fetal life may program the development of asthma during childhood.
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影响因子：
4.4
作者：
Pincus-Knackstedt, Maike K.;Joachim, Ricarda A.;Arck, Petra C.
通讯作者：
Arck, Petra C.
影响因子：
1.5
作者：
Hobel, Calvin J.;Goldstein, Amy;Barrett, Emily S.
通讯作者：
Barrett, Emily S.
DOI：
10.1111/j.2044-8341.1988.tb02787.x
发表时间：
1988-09-01
期刊：
BRITISH JOURNAL OF MEDICAL PSYCHOLOGY
影响因子：
--
作者：
BIRTCHNELL, J;EVANS, C;KENNARD, J
通讯作者：
KENNARD, J
影响因子：
3.7
作者：
Oberlander, Tim F.;Weinberg, Joanne;Devlin, Angela M.
通讯作者：
Devlin, Angela M.
DOI：
10.1097/00004583-200212000-00019
发表时间：
2002-12-01
影响因子：
13.3
作者：
O'Connor, TG;Heron, J;Glover, V
通讯作者：
Glover, V