EPIDEMIOLOGIC STUDIES OF STREPTOCOCCUS-PNEUMONIAE IN INFANTS - ACQUISITION, CARRIAGE, AND INFECTION DURING THE 1ST 24 MONTHS OF LIFE
EPIDEMIOLOGIC STUDIES OF STREPTOCOCCUS-PNEUMONIAE IN INFANTS - ACQUISITION, CARRIAGE, AND INFECTION DURING THE 1ST 24 MONTHS OF LIFE
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DOI：
10.1093/infdis/142.6.923
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
DILLON, HC
中科院分区：
文献类型：
--
作者：
GRAY, BM;CONVERSE, GM;DILLON, HC
本文报告82例新生儿肺炎球菌感染的自然史研究。纵向运输模式，确定了一系列的喉咙和nasopharynygia文化。在研究期间，79名婴儿携带1种或多种类型。第一种类型是在平均6个月时获得的，携带的时间随着携带的类型的连续而减少。新类型的采购在冬季达到高峰，但运输率全年波动。在24名婴儿中记录了31例肺炎球菌感染：28例中耳炎，2例菌血症和1例脑膜炎。致病类型与常见携带类型相似（6、14、19和23）。感染多发生在1个月内。获得一种新的类型，很少与长期运输。在暴露于新菌株方面，15%（196例中的31例）的获得导致了疾病。
A natural history study of pneumococcal infection in 82 infants followed from birth is reported. Longitudinal carriage patterns were determined by serial throat and nasopharnygeal cultures. Seventy-nine infants carried 1 or more types during the study period. The 1st type was acquired by a mean age of 6 mo., and the duration of carriage decreased with successive types carried. Acquisition of new types peaked in winter months but carriage rates fluctuated throughout the year. Thirty-one pneumococcal infections were documented in 24 infants: 28 episodes of otitis media, 2 of bacteremia and one of meningitis. Types causing disease were similar to commonly carried types (6, 14, 19 and 23). Infection usually occurred within 1 mo. of acquisition of a new type and was seldom associated with prolonged carriage. In terms of exposure to new strains, 15% (31 of 196) of acquisition resulted in disease.