Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia
Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia
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DOI：
10.1016/j.dadm.2018.12.006
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发表时间：
2019-12-01
影响因子：
5.3
通讯作者：
Rohrer, Jonathan D.
中科院分区：
文献类型：
--
作者：
Bocchetta, Martina;Iglesias, Juan Eugenio;Rohrer, Jonathan D.
额颞叶痴呆（FTD）是一种异质性神经退行性疾病，具有多种遗传和病理原因。其特征是皮质和皮质下萎缩，先前的研究表明杏仁核早期受累。然而，没有先前的研究专门调查了萎缩的不同亚核的杏仁核。方法：使用自动分割工具的T1加权容积磁共振成像，我们调查了杏仁核亚核（AS）参与一个队列的132例患者的遗传或病理证实的FTD（年龄：平均= 61岁（标准差= 8）;病程：5（3）年）与107名年龄匹配的对照组进行比较。MAPT突变/FTDP-17、皮克病和反式反应DNA结合蛋白43 kDa C型是杏仁核最小的形式（在最受影响的半球中比对照小35%-50%，P <0.0005）。在大多数FTD组，内侧亚核（特别是浅表，附件基底和基底/小脑亚核）往往受到影响超过外侧亚核，除了进行性核上性麻痹组，其中皮质杏仁过渡区是受影响最小的区域。一般而言，受影响最大的亚核是浅表、副基底和基底/小脑亚核，它们构成了控制奖赏和情绪调节的区域网络的一部分，已知这些功能在FTD中特别受影响。(C)2019作者爱思唯尔公司出版代表老年痴呆症协会
Introduction: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder with multiple genetic and pathological causes. It is characterized by both cortical and subcortical atrophies, with previous studies showing early involvement of the amygdala. However, no prior study has specifically investigated the atrophy of different subnuclei of the amygdala.Methods: Using an automated segmentation tool for T1-weighted volumetric magnetic resonance imaging, we investigated amygdalar subnuclei (AS) involvement in a cohort of 132 patients with genetic or pathologically confirmed FTD (age: mean = 61 years (standard deviation = 8); disease duration: 5 (3) years) compared with 107 age-matched controls.Results: AS were affected in all genetic and pathological forms of FTD. MAPT mutations/FTDP-17, Pick's disease, and transactive response DNA binding protein 43 kDa type C were the forms with the smallest amygdala (35%-50% smaller than controls in the most affected hemisphere, P < .0005). In most FTD groups, medial subnuclei (particularly the superficial, accessory basal and basal/paralaminar subnuclei) tended to be affected more than the lateral subnuclei, except for the progressive supranuclear palsy group, in which the corticoamygdaloid transition area was the least-affected area.Discussion: Differential involvement of the AS was seen in the different genetic and pathological forms of FTD. In general, the most affected subnuclei were the superficial, accessory basal and basal/paralaminar subnuclei, which form part of a network of regions that control reward and emotion regulation, functions known to be particularly affected in FTD. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.