FICTIVE COUGH IN THE CAT
FICTIVE COUGH IN THE CAT
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DOI：
10.1152/jappl.1991.71.6.2325
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发表时间：
1991-12-01
影响因子：
3.3
通讯作者：
BOLSER, DC
中科院分区：
文献类型：
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作者：
BOLSER, DC
进行实验以确定在呼吸循环触发泵上通气的瘫痪猫中是否可以引起咳嗽。将中丘去脑猫麻痹并在膈触发泵上人工通气。记录膈神经和髂腹下颅神经传出活动。通过电刺激上级层神经（SLN）或探查胸内气管引起咳嗽。由电刺激SLN或机械刺激胸内气管引起的虚构咳嗽包括膈神经放电的大幅度爆发，紧接着是颅髂腹下放电的大爆发。在虚拟咳嗽期间，膈吸气后放电相对于对照周期减少。可待因（0.03-1 mg/kg iv）降低SLN和探针诱导的虚构咳嗽。我的结论是，虚构的咳嗽可以产生在瘫痪猫通气膈触发泵。此外，在没有与主动呼气相关联的传入反馈的情况下，可以产生虚构的咳嗽。
Experiments were performed to determine whether cough could be elicited in paralyzed cats ventilated on a respiratory cycle-triggered pump. Midcollicular decerebrate cats were paralyzed and artificially ventilated on a phrenic-triggered pump. Phrenic and cranial iliohypogastric nerve efferent activities were recorded. Cough was elicited by electrical stimulation of the superior layngeal nerve (SLN) or probing the intrathoracic trachea. Fictive coughs induced by electrical stimulation of the SLN or mechanical stimulation of the intrathoracic trachea consisted of large-amplitude bursts in phrenic discharge immediately followed by large bursts in cranial iliohypogastric discharge. During fictive cough, phrenic postinspiratory discharge was reduced relative to control cycles. Codeine (0.03-1 mg/kg iv) decreased both SLN- and probe-induced fictive cough. I conclude that fictive cough can be produced in paralyzed cats ventilated on a phrenic-triggered pump. Furthermore, fictive cough can be produced in the absence of afferent feedback associated with active expiration.