Thermoresponsive Homopolymer Tunable by pH and CO2
Thermoresponsive Homopolymer Tunable by pH and CO2
复制标题
可通过 pH 和 CO2 调节的热响应均聚物
DOI：
10.1021/mz5005822
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发表时间：
2014-11-01
影响因子：
7.015
通讯作者：
Huang, Xiaoyu
中科院分区：
文献类型：
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作者：
Jiang, Xue;Feng, Chun;Huang, Xiaoyu
通过氮杂-迈克尔加成反应，与丙烯酰氯进行酰胺化反应，合成了侧链含有N，N-二乙氨基乙基和异丙酰胺的丙烯酰胺单体N-(2-(diethylamino)ethyl)-N-(3-(isopropylarnino)-3-oxopropyl)acrylamide(DEAENIPAMAM)。然后通过RAFT聚合制备了相对分子质量可控、相对分子质量分布较窄的均聚物poly(N-(2(-diethylarnino)ethyl)-N-(3-(isopropylamino)-3-oxopropyl)-(丙烯酰胺)S[Poly(DEAE-NIPAM-AM)]。考察了均聚物的低临界溶解温度(LCST)受水溶液相对分子质量、盐浓度和pH值的影响。通过改变水溶液的pH值可以在较宽的温度范围内调节均聚物的LC_(ST)，并且随着pH值的降低，LC_(ST)增大。特别是，CO2气体作为一种独特的pH刺激，也可以在不添加添加剂或碱的情况下可逆地调节均聚物的溶解度。
A new acrylamide monomer bearing isopropylamide and N,N-diethylamino ethyl groups in the side chain, i.e., N-(2-(diethylamino)ethyl)-N-(3-(isopropylarnino)-3-oxopropyl)acrylamide (DEAE-NIPAM-AM), was synthesized through Aza-Michael addition reaction followed by amidation with acryloyl chloride. The homopolymers, poly(N-(2(-diethylarnino)ethyl)-N-(3-(isopropylamino)-3-oxopropyl)- acrylarnide)s [poly(DEAE-NIPAM-AM)], with controlled molecular weights and relatively narrow molecular weight distributions were then prepared via RAFT polymerization. The lower critical solution temperature (LCST) of the homopolymer was examined to be influenced by molecular weight, salt concentration, and pH value of aqueous solution. The LCST of the homopolymer could be tuned in a wide temperature window by changing the pH value of aqueous solution, and it increased with the decrease of pH value. Particularly, CO2 gas as a unique pH stimulus can also reversibly adjust the solubility of homopolymer without the addition of adds or bases.