Lucid Dreaming in Narcolepsy
Lucid Dreaming in Narcolepsy
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DOI：
10.5665/sleep.4516
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发表时间：
2015-03-01
期刊：
影响因子：
5.6
通讯作者：
Arnulf, Isabelle
中科院分区：
文献类型：
--
作者：
Dodet, Pauline;Chavez, Mario;Arnulf, Isabelle
目的：探讨发作性睡病患者做清醒梦的频率、影响因素和睡眠特征。设计：病例对照研究。受试者：连续入睡的发作性睡病患者和健康对照组。12名发作性睡病患者和5名自称经常做清醒梦的对照组在得到如何在清醒时发出眼睛信号的指导后，进行了夜间和日间睡眠监测。结果：与53名健康对照组相比，53名发作性睡病患者报告了更频繁的梦回忆、噩梦和反复做梦。77.4%的发作性睡病患者和49.1%的对照组实现了清醒梦(P<；0.0001)，平均每月有7.6%+/-11vs.0.3+/-0.8次清醒梦(P<；005)。有无清醒梦的发作性睡病患者的猝倒、幻觉、睡眠瘫痪、睡眠障碍、人类白细胞抗原阳性和嗜睡的严重程度相似。12名发作性睡眠症患者(0名非发作性睡眠者)中有7人在总共33次午睡中实现了清醒的快速眼动睡眠，其中14次伴有眼球信号。在频谱脑电分析中，清醒的REM睡眠中电极平均的Delta功率、Delta、Theta和C4的α功率以及额叶电极之间的一致性低于非清醒的REM睡眠。清醒组与非清醒组REM睡眠持续时间较长，REM入睡潜伏期较短，紧张症发生率较高，觉醒指数、REM密度及波幅无明显变化。结论：发作性睡病患者与无发作性睡眠者相比，有较高的清醒梦倾向，但REM睡眠特征无明显差异。这表明发作性睡病患者可能会在未来关于清醒梦本质的研究中提供有用的信息。
Objective: To evaluate the frequency, determinants and sleep characteristics of lucid dreaming in narcolepsySettings: University hospital sleep disorder unitDesign: Case-control studyParticipants: Consecutive patients with narcolepsy and healthy controlsMethods: Participants were interviewed regarding the frequency and determinants of lucid dreaming. Twelve narcolepsy patients and 5 controls who self-identified as frequent lucid dreamers underwent nighttime and daytime sleep monitoring after being given instructions regarding how to give an eye signal when lucid.Results: Compared to 53 healthy controls, the 53 narcolepsy patients reported more frequent dream recall, nightmares and recurrent dreams. Lucid dreaming was achieved by 77.4% of narcoleptic patients and 49.1% of controls (P < 0.05), with an average of 7.6 +/- 11 vs. 0.3 +/- 0.8 lucid dreams/month (P < 0.0001). The frequency of cataplexy, hallucinations, sleep paralysis, dyssomnia, HLA positivity, and the severity of sleepiness were similar in narcolepsy with and without lucid dreaming. Seven of 12 narcoleptic (and 0 non-narcoleptic) lucid dreamers achieved lucid REM sleep across a total of 33 naps, including 14 episodes with eye signal. The delta power in the electrode average, in delta, theta, and alpha powers in C4, and coherences between frontal electrodes were lower in lucid than non-lucid REM sleep in spectral EEG analysis. The duration of REM sleep was longer, the REM sleep onset latency tended to be shorter, and the percentage of atonia tended to be higher in lucid vs. non-lucid REM sleep; the arousal index and REM density and amplitude were unchanged.Conclusion: Narcoleptics have a high propensity for lucid dreaming without differing in REM sleep characteristics from people without narcolepsy. This suggests narcolepsy patients may provide useful information in future studies on the nature of lucid dreaming.