Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using Nucleophilic CF3SiMe3: Efficient C(sp3)-CF3 Bond Formation
Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using Nucleophilic CF3SiMe3: Efficient C(sp3)-CF3 Bond Formation
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DOI：
10.1021/ol300639a
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发表时间：
2012-04-20
期刊：
影响因子：
5.2
通讯作者：
Qing, Feng-Ling
中科院分区：
文献类型：
--
作者：
Chu, Lingling;Qing, Feng-Ling
利用cu催化末端烯烃的氧化三氟甲基化，在温和的条件下进行了一种高效的C(sp(3))-CF3成键反应，该反应使用易得且便宜的CF3SiMe3作为CF3基团的来源。该方法允许获得各种三氟甲基化烯丙基化合物。
An efficient C(sp(3))-CF3 bond-forming reaction via Cu-catalyzed oxidative trifluoromethylation of terminal alkenes has been developed, which proceeds under mild conditions using readily available, less expensive CF3SiMe3 as the source of the CF3 group. This method allows access to a variety of trifluoromethylated allylic compounds.