In-vitro venous prostacyclin production, plasma 6-keto-prostaglandin F1 alpha concentrations, and diabetic retinopathy.
In-vitro venous prostacyclin production, plasma 6-keto-prostaglandin F1 alpha concentrations, and diabetic retinopathy.
复制标题
体外静脉前列环素的产生、血浆 6-酮基前列腺素 F1 α 浓度和糖尿病视网膜病变。
DOI：
10.1136/bmj.282.6272.1259
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
R. Turner
中科院分区：
文献类型：
--
作者：
T. Davis;E. Bown;D. Finch;M. Mitchell;R. Turner
先前的研究表明，糖尿病患者的血管在体外产生的前列环素比正常对照组的少。为了确定这种减少是否与并发症有关，选择性活检前臂浅静脉进行12例胰岛素依赖型男性糖尿病患者，6例为零或最小，6例为增生性视网膜病变，7例男性对照。糖尿病患者和对照组的静脉节段在体外产生了相似量的前列环素（中位数分别为0.11和0.19 ng/mg组织），但无或轻微视网膜病变的糖尿病患者的静脉节段产生的前列环素少于增殖性视网膜病变的糖尿病患者的静脉节段（中位数分别为0.09和0.18 ng/mg）。对照组和糖尿病患者的术前血浆6-酮-前列腺素F1 α免疫反应浓度无显著差异（中位数分别为101和116 pg/ml）。然而，在一项单独的研究中，11名病程超过10年且无或轻微视网膜病变的糖尿病患者的浓度显著低于16名背景或增殖性视网膜病变患者（中位数分别为79和121 pg/ml）。这些结果不支持前列环素产生减少与糖尿病视网膜病变之间的关联。
Previous studies have shown that vessels from diabetics produce less prostacyclin in vitro than those from normal controls. To determine whether this decreased production is related to complications elective biopsy of a superficial forearm vein was performed on 12 insulin-dependent male diabetics, six with nil or minimal and six with proliferative retinopathy, and seven male controls. Vein segments from the diabetics and controls produced similar amounts of prostacyclin in vitro (medians 0.11 and 0.19 ng/mg tissue respectively), but the segments from the diabetics with nil or minimal retinopathy produced less than those from the diabetics with proliferative retinopathy (medians 0.09 and 0.18 ng/mg respectively). Preoperative plasma immunoreactive concentrations of 6-keto-prostaglandin F1 alpha were not significantly different between the controls and the diabetics (medians 101 and 116 pg/ml respectively). In a separate study, however, 11 diabetics with duration of disease of over 10 years and nil or minimal retinopathy had significantly lower concentrations than a matched group of 16 with background or proliferative retinopathy (medians 79 and 121 pg/ml respectively). These results do not support an association between reduced prostacyclin production and diabetic retinopathy.