P(O)R2-Directed Enantioselective C-H Olefination toward Chiral Atropoisomeric Phosphine-Olefin Compounds
P(O)R2-Directed Enantioselective C-H Olefination toward Chiral Atropoisomeric Phosphine-Olefin Compounds
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P(O)R-2 定向对映选择性 C-H 烯化制备手性阻转异构膦-烯烃化合物
DOI：
10.1021/acs.orglett.7b00608
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发表时间：
2017-04-07
期刊：
影响因子：
5.2
通讯作者：
Yang, Shang-Dong
中科院分区：
文献类型：
--
作者：
Li, Shi-Xia;Ma, Yan-Na;Yang, Shang-Dong
本文首次报道了钯催化对映选择性烃烯烃法合成手性atropoisomer biaryl phospine -烯烃化合物的研究进展。该反应操作简单，可耐受宽官能团，且具有良好的ee值。值得注意的是，P(O)R-2不仅作为指导C-H活化以生成有用的配体的指导基团，而且还有助于在该转化中以有用的方式促进产物的组成。
An effective synthesis of chiral atropoisomeric biaryl phosphine-olefin compounds via palladium-catalyzed enantioselective C-H olefination has been developed for the first time. The reactions are operationally simple, tolerate wide functional groups, and have a good ee value, Notably, P(O)R-2 not only acts as the directing group to direct C-H activation in order to make a useful ligand but also serves to facilitate composition of the product in a useful manner in this transformation.