An integrated magnetic spectrometer for multiplexed biosensing
An integrated magnetic spectrometer for multiplexed biosensing
复制标题
用于多重生物传感的集成磁谱仪
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
A. Hajimiri
中科院分区：
文献类型：
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作者：
Constantine Sideris;A. Hajimiri
对于家庭和护理点医疗诊断工具的需求很高，这是迈向快速，低成本，个人医疗的一步。基于磁性标记方案的集成生物传感器由于消除了光学器件而提供了更高的灵敏度和更低的成本，并且已经成为使用荧光进行生物分子检测的测定的可行替代方案。例如，[1]的频移传感器展示了CMOS中的成本有效的磁性粒子生物传感器的高灵敏度示例，而不需要外部磁体。尽管它们的成本和灵敏度的优势，磁性生物传感器报道，迄今为止遭受缺乏多探针诊断类似于基于荧光的方法，使用多种颜色的同时单点多目标区分。这主要是因为电流方法在低频[2，3]或固定RF频率[1]下测量磁化率χ的变化。因此，这些方法没有提供用于区分大量小磁性颗粒与具有类似磁性含量的较少数量的较大尺寸颗粒的清晰路径。
There is high demand for at-home and point-of-care medical diagnostic tools as a step toward fast, low-cost, personal medicine. Integrated biosensors based on magnetic labeling schemes offer higher sensitivity and lower cost due to the elimination of the optics and have emerged as a viable alternative to assays that use fluorescence for biomolecular detection. For instance, the frequency-shift sensor of [1] demonstrates a high-sensitivity example of a cost-effective magnetic particle biosensor in CMOS with no need for external magnets. Despite their cost and sensitivity advantages, magnetic biosensors reported so far suffer from a lack of multi-probe diagnostics similar to fluorescent-based approaches that use multiple colors for simultaneous single-site multiple target differentiation. This is primarily because current approaches measure changes in the magnetic susceptibility, χ, either at low frequencies [2,3] or at a fixed RF frequency [1]. Consequently, these approaches do not provide a clear path for differentiating between a large number of small magnetic particles vs. a smaller number of larger size particles with similar magnetic content.