[A case-control study on the risk factors for attempted suicide in patients with major depression].
[A case-control study on the risk factors for attempted suicide in patients with major depression].
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发表时间：
2007-02
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通讯作者：
Yuqi Zhang;G. Yuan;Gui-lin Li;Jian-jun Yao;Zao-huo Cheng;X. Chu;Chao-jun Liu;Qing-hai Liu;Aiqin Wang;Gui-zhi Shi;Bao-heng Wang;Yi-ren Cheng;Ming-lian Zhang;Ke Li
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作者：
Yuqi Zhang;G. Yuan;Gui-lin Li;Jian-jun Yao;Zao-huo Cheng;X. Chu;Chao-jun Liu;Qing-hai Liu;Aiqin Wang;Gui-zhi Shi;Bao-heng Wang;Yi-ren Cheng;Ming-lian Zhang;Ke Li
目的了解抑郁症患者自杀未遂的环境危险因素，探讨TPH 2基因rs7305115单核苷酸多态性（SNP）等因素与抑郁症自杀未遂的交互作用。方法采用配对病例对照研究方法，对215例抑郁症自杀未遂者（男92例，女123例）进行TPH 2基因rs7305115 SNP及相关环境因素与自杀未遂率的关系研究。对照组与病例组按性别相同、年龄相近（不超过3岁）、来自同一地区配对。结果病例组与对照组基因型和基因频率差异有非常显著性意义（P < 0.001）。多因素条件Logistic回归分析显示，绝望感、负性生活事件和自杀家族史是抑郁症患者自杀未遂的危险因素，OR值为0.33（95% CI：0.22-0.99）、7.68（95% CI：5.79-13.74）、6.64（95% CI：2.48-11.04）、2.98（95% CI：1.17-5.04）。两个风险因素之间没有一级相互作用。结论绝望感、负性生活事件和自杀家族史是抑郁症自杀未遂的危险因素，而TPH 2基因rs7305115 A/A可能是抑郁症自杀未遂的保护因素。
OBJECTIVE To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism(SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression. METHODS Paired case-control study on 215 suicide attempters with major depression (92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP,interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender, similar age (no more than 3 years) and from the same district. RESULTS There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness, negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 (95% CI: 0.22-0.99), 7.68 (95% CI: 5.79-13.74), 6.64 (95% CI: 2.48-11.04), 2.98 (95% CI: 1.17-5.04) respectively. There was no first level interaction between any of the two risk factors. CONCLUSION Results from the study supported the idea that hopelessness, negative life-events and family history of suicide were risk factors of attempted suicide in major deprbssion while TPH2 gene rs7305115 A/A might be the protective factor.