Gray and white matter changes in Alzheimer's disease: A diffusion tensor imaging study
Gray and white matter changes in Alzheimer's disease: A diffusion tensor imaging study
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DOI：
10.1002/jmri.21231
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Chalk, Jonathan B.
中科院分区：
文献类型：
--
作者：
Rose, Stephen E.;Janke, Andrew L.;Chalk, Jonathan B.
目的：利用扩散张量成像 (DTI) 研究阿尔茨海默病患者皮质和白质通路的微观结构变化。材料和方法：采用优化的 DTI，对 13 名阿尔茨海默病 (AD) 患者和一组 13 名年龄匹配的对照参与者的大脑中的平均扩散率 (MD) 和分数各向异性 (FA) 测量进行比较 结果：在严格控制解剖变异和混杂的部分体积效应后，我们发现 AD 参与者的海马体、杏仁核、内侧颞叶、顶叶和额叶灰质区域的 MD 测量值显着升高。 MD 增加的最大数量的像素位于双侧后扣带回内。丘脑、顶叶白质和内囊后肢内的 FA 显着减少，表明皮质丘脑和丘脑皮质辐射显着参与。结论：本研究表明，DTI 数据的严格 VBM 分析可用于研究 AD 中皮质、皮质下和白质区域的微观结构变化。
Purpose: To investigate microstructural changes in cortical and white matter pathways in patients with Alzheimer's disease using diffusion tensor imaging (DTI).Materials and Methods: Measures of mean diffusivity (MD) and fractional anisotropy (FA) were compared in the brains of 13 Alzheimer's disease (AD) patients and a group of 13 aged-matched control participants employing an optimized DTI technique involving a fully automated, voxel-based morphometric (VBM) analysis.Results: After rigorous control for anatomical variation and confounding partial volume effects, we found significantly elevated MD measures within the hippocampus, amygdala, and medial temporal, parietal, and frontal lobe gray matter regions in the AD participants. The largest number of pixels with increased MD was localized bilaterally, within the posterior cingulate gyrus. The FA was significantly reduced within the thalamus, parietal white matter, and posterior limbs of the internal capsule, indicating significant involvement of corticothalamic and thalamocortical radiations.Conclusion: This study demonstrates that rigorous VBM analysis of DTI data can be used to investigate microstructural changes in cortical, subcortical, and white matter regions in AD.