SUBCLASS DISTRIBUTION OF IGG AUTOANTIBODIES IN BULLOUS PEMPHIGOID
SUBCLASS DISTRIBUTION OF IGG AUTOANTIBODIES IN BULLOUS PEMPHIGOID
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DOI：
10.1111/1523-1747.ep12283737
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发表时间：
1986-01-01
影响因子：
6.5
通讯作者：
THOMPSON, RA
中科院分区：
文献类型：
--
作者：
BIRD, P;FRIEDMANN, PS;THOMPSON, RA
利用针对人IgG亚类的单克隆抗体分析了皮肤和血清中类天疱疮抗基底膜区自身抗体中IgG亚类的分布。主要亚类是 IgG4，在 24 份皮肤活检中的 23 份中存在，其次是 IgG1，仅偶尔发现 IgG3。在 24 份活检中有 3 份中，IgG4 是唯一检测到的 IgG 亚类，其中 2 份中不存在 C3，第三份含有 IgM 和 C3。当 IgG4 自身抗体再次成为主要亚类时，通过间接免疫荧光 (IIF) 类似地分析血清自身抗体。 IIF 未检测到 IgE 自身抗体。
The distribution of IgG subclasses in the antibasement membrane zone autoantibody of pemphigoid in skin and serum was analyzed by use of monoclonal antibodies to human IgG subclasses. The predominant subclass was IgG4 which was present in 23 of 24 skin biopsies, IgG1 was next and IgG3 was found only occasionally. In 3 of 24 biopsies IgG4 was the only IgG subclass detected, C3 was absent in 2 of these, the third contained IgM and C3. Serum autoantibodies were similarly analyzed by indirect immunofluorescence (IIF) when again IgG4 autoantibody was the dominant subclass. No IgE autoantibody was detected by IIF.