Intracerebral Hemorrhage: Blood Components and Neurotoxicity
Intracerebral Hemorrhage: Blood Components and Neurotoxicity
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DOI：
10.3390/brainsci9110316
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发表时间：
2019-11-01
期刊：
影响因子：
3.3
通讯作者：
Sukumari-Ramesh, Sangeetha
中科院分区：
文献类型：
--
作者：
Madangarli, Neha;Bonsack, Frederick;Sukumari-Ramesh, Sangeetha
脑出血（ICH）是卒中的一种亚型，在所有卒中中与最高的死亡率和发病率相关。虽然它是一个主要的公共卫生问题，但没有有效的治疗方法。作为ICH的结果，各种血液成分在脑实质中积聚，并导致许多继发性脑损伤和ICH诱导的神经功能缺损。因此，迫切需要能够减轻血液成分诱导的神经毒性并改善血肿消退的策略。本文综述了脑出血后血液诱导的脑损伤，并强调需要进行进一步的研究，阐明脑出血后血肿消退的机制。
Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH.