Correlation between serum IL-6 and CRP levels and severity of head injury in children
Correlation between serum IL-6 and CRP levels and severity of head injury in children
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DOI：
10.1007/s001340050837
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发表时间：
1999-03-01
影响因子：
38.9
通讯作者：
Papadatos, J
中科院分区：
文献类型：
--
作者：
Kalabalikis, P;Papazoglou, K;Papadatos, J
Objective: To examine interleukin-6 (IL-6) and C-reactive protein (CRP) release in children with head injury (WI) and investigate if there is a correlation between the levels of these two proteins and the severity of HI.Design: Prospective clinical investigation.Setting: Eight-bed paediatric intensive care unit in a university hospital.Patients: Forty-five children were followed up for 4 days after HI and their serum IL-6 and CRP levels were measured,Measurements and results: Peak serum IL-6 levels occurred 4 h postinjury, decreasing over time. CRP was normal 4 h after injury, then increased reaching peak levels in 48 h. Children with admission Glasgow Coma Scale (CCS) scores of 8 or less had higher IL-B levels compared to children with GCS scores higher than 8, 4 and 12 h post-injury (p < 0.01 and p < 0.05, respectively). IL-6 was higher in children with admission PRISM scores of 10 or more than in those with PRISM scores lower than 10 at 4 and 12 h (p < 0.05). GRP levels were higher in patients with GCS scores of 8 or less compared to patients with GCS scores higher than 8 at 24, 48 and 72 h (p < 0.05, p < 0.02 and p < 0.02, respectively). Patients with PRISM scores of 10 or more had higher CRP levels compared to those with PRISM scores lower than 10 at 24, 48 and 72 h (p < 0.05). Peak CRP levels correlated well with peak IL-6 levels (r = 0.49, p < 0.001). No correlation between IL-6 or CRP levels and mortality or clinical outcome was found.Conclusions: Serum IL-6 and CRP levels are elevated in children with HI and there is a relation between the severity of PII and the levels of these proteins. There was no correlation between IL-6, CRP and outcomes of the patients.
