AN OUTBREAK OF MAYARO VIRUS-DISEASE IN BELTERRA, BRAZIL .1. CLINICAL AND VIROLOGICAL FINDINGS
AN OUTBREAK OF MAYARO VIRUS-DISEASE IN BELTERRA, BRAZIL .1. CLINICAL AND VIROLOGICAL FINDINGS
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DOI：
10.4269/ajtmh.1981.30.674
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
LEDUC, JW
中科院分区：
文献类型：
--
作者：
PINHEIRO, FP;FREITAS, RB;LEDUC, JW
1978年上半年，在巴西帕拉州贝尔特拉发生了由Mayaro （MAY）病毒引起的人类疾病暴发。共确诊55例，其中43例经病毒分离和血清学检测，12例仅经血清学检测。Belterra的疾病表现为一种独特的临床综合征，以发热、关节痛和皮疹为特征。没有死亡可归因于五月病毒感染。20%的病例伴有关节水肿，关节痛是导致许多患者暂时丧失工作能力的突出症状。几乎所有确诊病例均出现关节痛，部分患者持续至少2个月，但严重程度有所下降。2/3的病例出现斑疹或微丘疹。皮疹在儿童中的发病率高于成人。与临床发病时开始的关节痛相反，皮疹通常在第5天出现，并在3-4天内消退。发热、寒战、头痛、肌痛、淋巴结病变等轻微临床表现也有记录，一般持续2-5天。白细胞减少是所有病例的常见病。25例患者中有4例出现轻度蛋白尿，20例中有10例出现轻度血小板减少。在10例患者中记录到的病毒血症水平为0.5 log/ml，这一事实提出了人类可能是may病毒周期中扩增宿主的可能性。如在Belterra所见，五月病毒病具有与基孔肯雅病毒感染者所见相似的临床特征。
An outbreak of human illness caused by Mayaro (MAY) virus occurred in Belterra, Para, Brazil in the 1st half of 1978. A total of 55 cases were confirmed, 43 by virus isolation and serology and 12 by serology alone. The disease in Belterra presented as a distinct clinical syndrome characterized by fever, arthralgia and exanthema. No fatalities could be attributed to MAY virus infection. Arthralgia, accompanied by joint edema in 20% of cases, was a prominent sign which caused temporary incapacity in many patients. Arthralgia was present in virtually all confirmed cases and persisted in some for at least 2 mo., although with decreasing severity. Rash was present in 2/3 of the cases and was maculopapular or micropapular. The incidence of rash was higher in children than in adults. Contrary to arthralgia, which started with the onset of clinical illness, rash usually appeared on the 5th day and faded within 3-4 days. Fever, chills, headache, myalgia, lymphadenopathy and other minor clinical manifestations were also recorded and generally persisted 2-5 days. Leukopenia was a constant finding in all cases. Mild albuminuria was seen in 4 of 25 patients and slight thrombocytopenia was seen in 10 of 20 cases. The fact that viremia levels > 5.0 log/ml of blood were recorded in 10 patients raises the possibility that man may be an amplifying host in the MAY virus cycle. The MAY virus illness, as seen in Belterra, has clinical features similar to those observed in persons infected with chikungunya virus.