Clinical and metabolic studies of chemically defined diets in the management of obesity.
Clinical and metabolic studies of chemically defined diets in the management of obesity.
复制标题
化学限定饮食在肥胖管理中的临床和代谢研究。
DOI：
10.1016/s0026-0495(74)80023-5
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
A. Howard
中科院分区：
文献类型：
--
作者：
I. Baird;R. Parsons;A. Howard
5名严重肥胖的受试者接受了长达1年的治疗，在代谢研究下，使用含有适当L-氨基酸（或蛋白质）、碳水化合物、维生素和矿物质的60-360千卡的化学定义饮食。患者对饮食的接受度非常高，很少抱怨饥饿。最佳每日制剂含有15 g氨基酸和30-45 g碳水化合物，可实现氮平衡，仅中度酮症，正常血清电解质和尿酸，平均体重减轻4.1 lb（1.8 kg）/周。观察到的临床异常为脱发、无色素性正色素性贫血、体位性低血压和高胆固醇血症。恢复正常饮食后，所有这些发现均恢复正常。低热量，化学定义的饮食约60-360千卡提供了一个可接受的和安全的形式比完全饥饿的体重减轻严重和难治性肥胖患者。
Five severely obese subjects were treatedfor up to 1 yr, under metabolic study, with chemically defined diets of 60–360 kcal containing appropriate L-amino acids (or protein), carbohydrates, vitamins, and minerals. Acceptance of the diets was excellent, and the patients rarely complained of hunger. The optimum daily formulation contained 15 g amino acids and 30–45 g carbohydrate which achieved nitrogen balance, only moderate ketosis, normal serum electrolytes and uric acid, and a mean weight loss of 4.1 Ib (1.8 kg)/week. Clinical abnormalities observed were alopecia, symptomless normochromic anemia, postural hypotension, and hypercholesterolemia. All these findings reverted to normal subsequent to resuming a normal diet. Low-calorie, chemically defined diets of approximately 60–360 kcal offer an acceptable and safer form of weight reduction than complete starvation in the severe and refractory obese patient.