Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents.
Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents.
复制标题
SIRT1 单核苷酸多态性与中国青少年反社会人格特质倾向之间可能存在关联。
DOI：
10.1038/s41598-017-01208-2
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发表时间：
2017-04-24
影响因子：
4.6
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Chang H;Yan Q;Tang J;Huang J;Zhang Y;Ma Y;Ye X;Tang L;Wu L;Wu C;Yu Y
越来越多的证据表明SIRT1基因与人类精神疾病之间存在关联。本研究旨在探讨SIRT1与中国青少年反社会人格特质（ASP）易感性的关系。参与者包括327名对照组和261名根据人格诊断问卷被诊断为有ASP倾向的少年犯。对SIRT1的4个标签单核苷酸多态性rs12778366、rs7896005、rs10823112和rs4746720进行基因分型。个体snp与ASP风险的关联分析显示，rs4746720 CC基因型与ASP风险降低显著相关（OR = 0.51, 95% CI = 0.33-0.77，调整后P = 0.007）。单倍型分析显示，TAAC单倍型与ASP易感性降低相关（OR = 0.72, 95% CI = 0.57-0.91, P = 0.005）。此外，发现rs4746720变异不仅对ASP易感性有直接影响，而且还调节饮酒的影响（Y = 0.022X + 0.431 vs. Y = - 0.066X + 0.387）。目前的研究首次报道了SIRT1多态性与青少年ASP之间的显著关联。这一发现有望帮助开发有效的干预措施，以治疗这种社会和个人代价高昂的疾病。
Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and 261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped. Association analysis between individual SNPs and ASP risk revealed the CC genotype of rs4746720 to be significantly associated with reduced risk of ASP (OR = 0.51, 95% CI = 0.33–0.77, adjusted P = 0.007). Haplotype analysis showed the TAAC haplotype was associated with reduced susceptibility to ASP (OR = 0.72, 95% CI = 0.57–0.91, P = 0.005). Moreover, rs4746720 variants were found to not only have a direct impact on ASP susceptibility but also modulate the effect of alcohol consumption (Y = 0.022X + 0.431 vs. Y = −0.066X + 0.387). The present study is the first to report a significant association between SIRT1 polymorphisms and ASP in adolescents. This finding is expected to aid in the development of effective interventions for this socially and personally costly disorder.