American Journal of Epidemiology Original Contribution Circulating 25-hydroxyvitamin D and Risk of Non-hodgkin Lymphoma Cohort Consortium Vitamin D Pooling Project of Rarer Cancers-猫眼课题宝

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M. Purdue;D. Freedman;S. Gapstur;K. Helzlsouer;F. Laden;U. Lim;G. Maskarinec;N. Rothman;X. Shu;V. Stevens;A. Zeleniuch‐Jacquotte;D. Albanes;K. Bertrand;S. Weinstein;Kai Yu;Lonn Irish;R. Horst;Judith A. Hoffman-Bolton;E. Giovannucci;L. Kolonel;Kirk Snyder;W. Willett;A. Arslan;R. Hayes;W. Zheng;Y. Xiang;P. Hartge

它允许在任何媒体上不受限制的非商业性使用、分发和复制，前提是适当引用原始作品。病例对照研究通常表明阳光照射和非霍奇金淋巴瘤（NHL）之间存在负相关，这导致了维生素D可能预防淋巴瘤的猜测。为了检验这一假设，作者对参与罕见癌症队列联盟维生素D汇集项目的10个队列中的循环25-羟基维生素D（25（OH）D）和随后的NHL风险进行了汇总调查。作者使用条件Logistic回归和其他方法分析了1,353例病例和1,778例对照的测量值，以估计25（OH）D与NHL的相关性。总体（P趋势<$0.68）或按性别（男性，P趋势<$0.50;女性，P趋势<$0.16）未观察到25（OH）D浓度类别与NHL之间存在关联的明确证据。其他测量结果（连续log（25（OH）D），使用性别/队列/季节特异性四分位数作为截断点的25（OH）D类别，使用四分位数作为截断点的预测25（OH）D季节调整残差类别）通常为零，尽管一些增加25（OH）D的测量结果提示女性风险增加。分层分析和NHL组织学亚型调查的结果也为零。这些发现不支持循环25（OH）D浓度升高与NHL风险降低相关的假设。未来的研究调查的生物学基础的阳光-NHL协会应考虑替代机制，如免疫学效应。流行病学研究结果通常表明，暴露于太阳紫外线辐射可能与非霍奇金淋巴瘤（NHL）的风险降低有关（1）。在美国和欧洲部分地区，环境紫外线辐射水平的增加（或作为替代，纬度的降低）与NHL发病率或死亡率的降低有关（2-5），尽管也有相互矛盾的生态学发现（6-8）。来自澳大利亚、欧洲和美国的几项病例对照研究也观察到NHL风险随着自我报告的终生阳光暴露的增加而降低（9-14），尽管在基于美国人群的研究中观察到与NHL风险增加相关。

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Case-control studies generally suggesting an inverse association between sun exposure and non-Hodgkin lymphoma (NHL) have led to speculation that vitamin D may protect against lymphomagenesis. To examine this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D (25(OH)D) and subsequent NHL risk within 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. The authors analyzed measurements from 1,353 cases and 1,778 controls using conditional logistic regression and other methods to estimate the association of 25(OH)D with NHL. No clear evidence of association between categories of 25(OH)D concentration and NHL was observed overall (P trend ¼ 0.68) or by sex (men, P trend ¼ 0.50; women, P trend ¼ 0.16). Findings for other measures (continuous log(25(OH)D), categories of 25(OH)D using sex-/cohort-/season-specific quartiles as cutpoints, categories of season-adjusted residuals of predicted 25(OH)D using quartiles as cutpoints) were generally null, although some measures of increasing 25(OH)D were suggestive of an increased risk for women. Results from stratified analyses and investigations of histologic subtypes of NHL were also null. These findings do not support the hypothesis that elevated circulating 25(OH)D concentration is associated with a reduced risk of NHL. Future research investigating the biologic basis for the sunlight–NHL association should consider alternative mechanisms, such as immunologic effects. Epidemiologic findings generally suggest that exposure to solar ultraviolet radiation may be associated with a reduced risk of non-Hodgkin lymphoma (NHL) (1). Increasing ambient ultraviolet radiation levels (or, as a proxy, decreasing latitude) have been associated with decreasing NHL incidence or mortality rates in the United States and some parts of Europe (2–5), although conflicting ecologic findings have also been reported (6–8). Several case-control studies from Australia, Europe, and the United States have also observed decreasing risks of NHL with increasing self-reported lifetime sun exposure (9–14), although an association with increased NHL risk was observed in a US population-based

American Journal of Epidemiology Original Contribution Circulating 25-hydroxyvitamin D and Risk of Non-hodgkin Lymphoma Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

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