Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters
Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters
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DOI：
10.1039/b811169c
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发表时间：
2008-01-01
期刊：
影响因子：
6.1
通讯作者：
Ahn, Chong H.
中科院分区：
文献类型：
--
作者：
Do, Jaephil;Lee, Sehwan;Ahn, Chong H.
本文介绍了一种易于操作的一次性临床诊断芯片实验室的开发，该实验室使用完全集成的塑料微流体组件，具有采样/识别能力，可以快速可靠地测量人体全血的代谢参数。已经开发了一种智能和功能的芯片上实验室墨盒，它包含了用于现场应用的完整芯片上自动校准功能，然后使用具有多分析物检测能力的便携式分析仪（3（1/4）“x 5”x 1”）进行了全面表征。此外，在聚合物上实现智能和功能的芯片实验室的几种新方法已被采用，其中包括用于自动流体密封的夹管阀，作为采样指示器的旁路通道，以及用于延长分析仪寿命的坚固连接器设计。代谢参数，如葡萄糖，乳酸和部分氧气从人全血已成功测量使用功能聚合物实验室芯片和便携式分析仪在这项工作中开发的。
This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-achip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3(1/4)'' x 5 '' x 1 '') with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes. Metabolic parameters such as glucose, lactate, and partial oxygen from human whole blood have been successfully measured using the functional polymer lab-on-a-chips and the portable analyzer developed in this work.