Non-responders to hepatitis B vaccination: a review.
Non-responders to hepatitis B vaccination: a review.
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对乙型肝炎疫苗接种无反应者：回顾。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
S. Strobel
中科院分区：
文献类型：
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作者：
A. Kubba;P. Taylor;B. Graneek;S. Strobel
B型肝炎病毒（HBV）感染是世界范围内的一个重大公共卫生问题，对高危人群进行疫苗接种是遏制HBV感染的主要方法。在健康的接种者中，5-10%不能产生足够的抗体反应。随着时间的推移，另一部分未知的疫苗接种者的抗体水平大幅下降，使他们处于潜在的感染风险中。本文的范围是审查可能影响HBV疫苗接种免疫应答的因素，审查用于克服应答差问题的方法，并讨论在治疗这些疫苗接种者时可用或需要哪些可能的指南。
Hepatitis B virus (HBV) infection is a major public health issue throughout the world and vaccination of those at risk is the main method of containment. Of healthy vaccinees, 5-10% fail to mount an adequate antibody response. The antibody levels of an unknown further fraction of vaccinees fall considerably over time rendering them at a potential risk of infection. The scope of this article is to review the factors that might influence the immune response to HBV vaccination, to review the methods used to overcome the problem of poor response and to discuss what possible guidelines are available or needed in treating these vaccinees.