Analysis of llicit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography - Electrospray tandem mass spectrometry (HPLC-MS/MS)
Analysis of llicit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography - Electrospray tandem mass spectrometry (HPLC-MS/MS)
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DOI：
10.1016/j.chemosphere.2010.08.011
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发表时间：
2010-11-01
期刊：
影响因子：
8.8
通讯作者：
Mathieu, Christoph
中科院分区：
文献类型：
--
作者：
Berset, Jean-Daniel;Brenneisen, Rudolf;Mathieu, Christoph
合法药物和非法药物是最近出现的一类污染物，已在水生环境中发现。开发了HPLC-MS/MS方法，使用较大体积的直接进样（DI）和极性封端的反相（RP）柱来测量水样中属于可卡因类阿片类药物安非他明类药物的药物成分。在包括灵敏度、线性、回收率、精密度和基质效应研究在内的验证之后，大多数药物可以用定量限（LOQ）检测。废水中的浓度为20 ng L-1，地表水中的浓度为02 ng L-1。在流入和流出物中发现的主要物质是可卡因（COC）、苯甲酰芽子碱（BE）、吗啡（MO）、美沙酮（MD）及其主要代谢产物2-亚乙基-15-二甲基-33-二苯基吡咯烷（EDDP），浓度可达2 μ g L-1，其次是可待因（COD）。除MO、COD和EDDP外，河水和湖水中主要含有痕量的BEMD和EDDP，从高pg L ~（-1）到低ng L ~（-1）连续11天监测流入物和流出物中的COC和BE水平表明消费偏好在周末最后测量一次大型音乐活动后的流入物显示，污水处理厂（STP）在有限的时间内暴露于COC和BE的高浓度峰值以及安非他明类兴奋剂，如摇头丸（MDMA）（C）2010 Elsevier Ltd版权所有
Llicit and illicit drugs represent a recent group of emerging contaminants and have been found in the aquatic environment A HPLC-MS/MS method was developed using direct injection (DI) of larger volumes and a polar endcapped reversed-phase (RP) column to measure drug components in water samples belonging to the cocaine group opiates amphetamine-like stimulants and metabolites thereof After validation including sensitivity linearity recovery precision and matrix effect studies most drugs could be detected with limits of quantitation (LOQ) of 20 ng L-1 in wastewater (WW) and 0 2 ng L-1 in surface water The major substances found in influents and effluents were cocaine (COC) benzoylecgonine (BE) morphine (MO) methadone (MD) and its main metabolite 2 ethylidene-1 5-dimethyl 3 3-diphenyl-pyrrolidine (EDDP) with concentrations up to 2 mu g L-1 followed by codeine (COD) and the amphetamines which ranged between 20 and 400 ng L-1 Except for MO COD and EDDP levels were generally lower in the effluents River and lake water contained trace amounts of mainly BE MD and EDDP from the high pg L-1 to the low ng L-1 level Monitoring COC and BE levels over 11 consecutive days in influents and effluents suggests a consumption preference on week-end days Finally measuring an influent after a major music event revealed that sewage treatment plants (STPs) are exposed for a limited period of time to high concentration peaks of COC and BE as well as amphetamine like stimulants such as ecstasy (MDMA) (C) 2010 Elsevier Ltd All rights reserved