INVESTIGATION OF CORONARY HEART-DISEASE IN FAMILIES - FRAMINGHAM OFFSPRING STUDY
INVESTIGATION OF CORONARY HEART-DISEASE IN FAMILIES - FRAMINGHAM OFFSPRING STUDY
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DOI：
10.1093/oxfordjournals.aje.a112813
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发表时间：
1979-01-01
影响因子：
5
通讯作者：
CASTELLI, WP
中科院分区：
文献类型：
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作者：
KANNEL, WB;FEINLEIB, M;CASTELLI, WP
FHS研究始于1948年，是对美国马萨诸塞州成年男性和女性心血管疾病的前瞻性研究。通过两年一次的体格检查，对5209例受试者的样本进行持续监测。1971年，开始对FHS队列的儿童进行检查。这项研究被称为FOS研究，扩大了对心血管疾病的认识，特别是在疾病及其危险因素的家族聚集性方面。FHS的抽样设计进行审查和FOS样品的性质进行了说明。FOS家庭显然是父母出生于19世纪末或世纪初的家庭的典型规模和年龄结构。很少有证据表明，冠心病（CHD）的经验和CHD的危险因素不同的父母谁自愿参加这项研究和那些谁没有志愿者的父母。
The Framingham Heart Study (FHS) was started in 1948 as a prospective investigation of cardiovascular disease in adult men and women from Massachusetts, USA. Continuous surveillance of this sample of 5209 subjects was maintained through biennial physical examinations. In 1971 examinations were begun on the children of the FHS cohort. This study called the Farmingham Offspring Study (FOS), expanded the knowledge of cardiovascular disease, particularly in the area of familial clustering of the disease and its risk factors. The sampling design of the FHS is reviewed and the nature of the FOS sample is described. The FOS families apparently are typical size and age structure for families with parents born in the late 19th or early 20th century. There is little evidence that coronary heart disease (CHD) experience and CHD risk factors differ in parents of those who volunteered for this study and the parents of those who did not volunteer.