Hydrogels synthesised through photoinitiator-free photopolymerisation technique for delivering drugs including a tumour-tracing porphyrin
Hydrogels synthesised through photoinitiator-free photopolymerisation technique for delivering drugs including a tumour-tracing porphyrin
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DOI：
10.1016/j.radphyschem.2005.11.006
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发表时间：
2006-05-01
影响因子：
2.9
通讯作者：
Gordon-Thomson, C
中科院分区：
文献类型：
--
作者：
Ng, LT;Swami, S;Gordon-Thomson, C
水凝胶的合成使用的光引发剂自由的光聚合技术，涉及供体/受体对之间的相互作用，用于提供不同分子量的药物，包括卟啉用作肿瘤示踪剂。受体N-（5-羟基）戊基马来酰亚胺与N-乙烯基-2-吡咯烷酮、甲基丙烯酸2-羟乙酯和N-乙烯基己内酰胺形成水凝胶。葡萄糖胺，一个有效的H-供体在增强聚合所示的差示光量热法的结果，被发现不适合水凝胶的制备。讨论了不同分子量的药物以相同速率释放的问题。发现水凝胶没有毒性作用，并且与人角质形成细胞系生物相容。(c)2005爱思唯尔有限公司保留所有权利。
Hydrogels were synthesised using the photoinitiator-free photopolymerisation technique involving interactions between donor/acceptor pairs for delivering drugs of different molecular weights including a porphyrin used as a tumour-tracing agent. N-(5-hydroxy) pentylmaleimide, an acceptor, formed hydrogels with N-vinyl-2-pyrrolidinone, 2-hydroxyethyl methacrylate and N-vinylcaprolactum. Glucosamine, an effective H-donor in enhancing polymerisation as shown by Differential Photocalorimetric results, was found unsuitable for hydrogel preparation. Drugs of different molecular weights releasing at the same rate was discussed. The hydrogels were found to have no toxic effects and were biocompatible with a human keratinocyte cell line. (c) 2005 Elsevier Ltd. All rights reserved.