Ultrasound exposure (mechanical index 1.8) with acoustic radiation force impulse evokes extrasystolic waves in rabbit heart under concomitant administration of an ultrasound contrast agent
Ultrasound exposure (mechanical index 1.8) with acoustic radiation force impulse evokes extrasystolic waves in rabbit heart under concomitant administration of an ultrasound contrast agent
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超声波照射（机械指数 1.8）与声辐射力脉冲在同时给予超声波造影剂的情况下在兔心脏中诱发期外收缩波
DOI：
10.1007/s10396-015-0654-0
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发表时间：
2016
影响因子：
1.8
通讯作者：
Iwaki Akiyama
中科院分区：
文献类型：
--
作者：
Yasunao Ishiguro;Naotaka Nitta;Nobuyuki Taniguchi;Kazuki Akai;Noriya Takayama;Hideki Sasanuma;Yukiyo Ogata;Yoshikazu Yasuda;Iwaki Akiyama
声辐射力脉冲(ARFI)是一种利用剪切波对各种器官进行弹性成像的方式。在某些情况下，心脏是ARFI弹性评估的候选对象。此外，超声造影剂(UCA)可提供有关心肌血流状况的信息。本研究旨在评价ARFI联合UCA给药(即全氟丁烷)对心脏的影响。方法用单元件聚焦换能器对雄性日本大白兔(n=3)的心脏进行超声检查。他们被暴露在机械指数(MI)为1.8的超声波下，时间为0.3毫秒。UCA有两种给药方式：单次(团注)注射或滴注。记录心电图以识别超声暴露时的心律失常。结果超声暴露后滴注UCA可观察到早搏波。未观察到危及生命的心律失常。额外波频率为4.2~59.6%。结论超声心动图(MI 1.8)与ARFI联合应用UCA时，可观察到兔心律失常的发生。尽管UCA的团注给药与临床应用相似，可能不会引起额外的心脏兴奋，但ARFI心脏超声检查应谨慎进行，特别是在联合使用UCA的情况下。
PurposeAcoustic radiation force impulse (ARFI) is a modality for elasticity imaging of various organs using shear waves. In some situations, the heart is a candidate for elasticity evaluation with ARFI. Additionally, an ultrasound contrast agent (UCA) provides information on the blood flow conditions of the cardiac muscle. This study aimed to evaluate ARFI’s effect on the heart concomitantly with UCA administration (i.e., perfluorobutane).MethodsUltrasound with ARFI was applied to the hearts of male Japanese white rabbits (n= 3) using a single-element focused transducer with or without UCA administration. They were exposed to ultrasound for 0.3 ms with a mechanical index (MI) of 1.8. UCA was administered in two ways: a single (bolus) injection or drip infusion. Electrocardiograms were recorded to identify arrhythmias during ultrasound exposure.ResultsExtrasystolic waves were observed following ultrasound exposure with drip infusion of UCA. Life-threatening arrhythmia was not observed. The frequency of the extra waves ranged from 4.2 to 59.6 %. With bolus infusion, extra waves were not observed.ConclusionsArrhythmogenicity was observed during ultrasound (MI 1.8) with ARFI and concomitant administration of UCA in rabbits. Although the bolus administration of UCA was similar to its clinical use, which may not cause extra cardiac excitation, cardiac ultrasound examinations with ARFI should be carefully performed, particularly with concomitant use of UCA.