Auditory dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy
Auditory dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy
复制标题
慢性炎症性脱髓鞘性多发性神经根神经病的听觉功能障碍
DOI：
10.1212/01.wnl.0000120662.29421.46
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发表时间：
2004
期刊：
影响因子：
9.9
通讯作者：
M. Zwarts
中科院分区：
文献类型：
--
作者：
G. Hengstman;H. J. Schelhaas;M. Zwarts
在慢性炎性脱髓鞘性多发性神经根神经病（CIDP）中报告了颅神经受累，最常见的是影响面神经和眼神经。1，2 <$前庭蜗神经的症状受累至少有一次描述，但仅在神经的前庭部分。1
我们描述了一个病人谁提出了复发的CIDP伴随着突然双侧感音神经性听力损失。脑干听觉诱发电位（BAEPs）证实双侧耳蜗后功能障碍。大剂量泼尼松治疗与临床和神经生理学几乎完全恢复相关。
一位66岁男性因突发性双侧听力丧失和下肢感觉异常寻求治疗。10个月前，CIDP已经基于临床体征和症状（对称性肌无力、感觉性共济失调、远端感觉减退和腱反射缺失）、神经传导研究的结果（即，尺神经和正中神经运动远端潜伏期和F波>正常值上限的130%，尺神经和腓神经传导速度减慢<正常值下限的70%，尺神经和正中神经存在传导阻滞。
Cranial nerve involvement, most commonly affecting the facial and oculomotor nerves, has been reported in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).1,2⇓ Symptomatic involvement of the vestibulocochlear nerve has been described at least once but only in the vestibular part of the nerve.1
We describe a patient who presented with a relapse of CIDP accompanied by sudden bilateral sensorineural hearing loss. Brainstem auditory evoked potentials (BAEPs) confirmed bilateral retrocochlear dysfunction. Treatment with high-dose prednisone was associated with nearly complete recovery clinically and neurophysiologically.
A 66-year-old man sought treatment for sudden bilateral hearing loss and paraesthesias of the lower extremities. Ten months earlier, CIDP had been diagnosed based on clinical signs and symptoms (symmetric muscle weakness, sensory ataxia, distal hypesthesia, and absent tendon reflexes), results of nerve conduction studies (i.e., motor distal latency and F waves of the ulnar and median nerves >130% of the upper limit of normal, slowing of nerve conduction velocities in ulnar and peroneal nerves <70% of the lower limit of normal, and presence of a conduction block in the …