A Comparison of Plasma Efavirenz and Tenofovir, Dried Blood Spot Tenofovir-Diphosphate, and Self-Reported Adherence to Predict Virologic Suppression Among South African Women
A Comparison of Plasma Efavirenz and Tenofovir, Dried Blood Spot Tenofovir-Diphosphate, and Self-Reported Adherence to Predict Virologic Suppression Among South African Women
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DOI：
10.1097/qai.0000000000002032
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发表时间：
2019-07-01
影响因子：
3.6
通讯作者：
Maartens, Gary
中科院分区：
文献类型：
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作者：
Phillips, Tamsin K.;Sinxadi, Phumla;Maartens, Gary
背景资料：替诺福韦-二磷酸盐（TFV-DP）在干血斑（DBS）是一个客观的长期坚持措施，但数据是有限的，其预测病毒学抑制（VS）的抗逆转录病毒（ARV）治疗的人的能力。也没有数据比较DBS TFV-DP与血浆ARV浓度作为VS的预测因子。方法：谁是一线方案替诺福韦，恩曲他滨和依法韦仑（EFV）的妇女参加了一项横断面研究。血浆EFV和替诺福韦（TFV）、DBS TFV-DP测定和30天自我报告的依从性被评估为VS的预测因子（
Background: Tenofovir-diphosphate (TFV-DP) in dried blood spots (DBS) is an objective long-term adherence measure, but data are limited on its ability to predict virologic suppression (VS) in people on antiretroviral (ARV) treatment. There are also no data comparing DBS TFV-DP with plasma ARV concentrations as predictors of VS.Methods: Women who were on a first-line regimen of tenofovir, emtricitabine, and efavirenz (EFV) were enrolled in a cross-sectional study. Plasma EFV and tenofovir (TFV), DBS TFV-DP assays, and 30-day self-reported adherence were evaluated as predictors of VS (