Sleep Regularity and Mortality: A Prospective Analysis in the UK Biobank.
Sleep Regularity and Mortality: A Prospective Analysis in the UK Biobank.
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睡眠规律和死亡率：英国生物库的前瞻性分析。
DOI：
10.1101/2023.04.14.23288550
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Pase,MatthewP
中科院分区：
文献类型：
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作者：
Cribb,Lachlan;Sha,Ramon;Yiallourou,Stephanie;Grima,NatalieA;Cavuoto,Marina;Baril,Andree-Ann;Pase,MatthewP
背景：不规则的睡眠-觉醒时间可能导致昼夜节律紊乱，从而导致几种慢性年龄相关疾病。我们研究了88,975名来自前瞻性英国生物银行队列的参与者的睡眠规律性与全因风险、心血管疾病（CVD）和癌症死亡率之间的关系。方法：睡眠规律性指数（SRI）计算为一个人在任何两个相隔24小时的时间点处于相同状态（睡眠或清醒）的概率，平均超过7天的加速度测量（范围0-100，100为完全规律）。结果：样本平均年龄为62岁（标准差[SD]，8），56%为女性，SRI中位数为60（SD，10）。在平均7.1年的随访期间，有3010例死亡。在对人口统计学和临床变量进行调整后，我们确定了SRI和全因死亡风险之间的非线性关系（p [总体样条项检验]< 0.001）。相对于中位SRI，SRI在第5百分位数（SRI= 41）的受试者和SRI在第95百分位数（SRI= 75）的受试者的风险比分别为1.53（95%置信区间[CI]：1.41，1.66）和0.90（95% CI：0.81，1.00）。CVD死亡率和癌症死亡率的发现遵循类似的模式。结论：不规则的睡眠-觉醒模式与更高的死亡风险相关。资金来源：澳大利亚国家健康和医学研究理事会（GTN 2009264; GTN 1158384），国家老龄化研究所（AG 062531），阿尔茨海默氏症协会（2018-AARG-591358）和班廷奖学金计划（# 454104）。
Background:Irregular sleep-wake timing may cause circadian disruption leading to several chronic age-related diseases. We examined the relationship between sleep regularity and risk of all-cause, cardiovascular disease (CVD), and cancer mortality in 88,975 participants from the prospective UK Biobank cohort.Methods:The sleep regularity index (SRI) was calculated as the probability of an individual being in the same state (asleep or awake) at any two time points 24 hr apart, averaged over 7 days of accelerometry (range 0–100, with 100 being perfectly regular). The SRI was related to the risk of mortality in time-to-event models.Results:The mean sample age was 62 years (standard deviation [SD], 8), 56% were women, and the median SRI was 60 (SD, 10). There were 3010 deaths during a mean follow-up of 7.1 years. Following adjustments for demographic and clinical variables, we identified a non-linear relationship between the SRI and all-cause mortality hazard (p [global test of spline term]< 0.001). Hazard ratios, relative to the median SRI, were 1.53 (95% confidence interval [CI]: 1.41, 1.66) for participants with SRI at the 5th percentile (SRI= 41) and 0.90 (95% CI: 0.81, 1.00) for those with SRI at the 95th percentile (SRI= 75), respectively. Findings for CVD mortality and cancer mortality followed a similar pattern.Conclusions:Irregular sleep-wake patterns are associated with higher mortality risk.Funding:National Health and Medical Research Council of Australia (GTN2009264; GTN1158384), National Institute on Aging (AG062531), Alzheimer’s Association (2018-AARG-591358), and the Banting Fellowship Program (# 454104).