Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys
Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys
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DOI：
10.1152/jn.1996.75.5.2144
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发表时间：
1996-05-01
影响因子：
2.5
通讯作者：
Milliken, GW
中科院分区：
文献类型：
--
作者：
Nudo, RJ;Milliken, GW
1.皮质内微刺激（ICMS）技术被用来获得详细的地图远端前肢运动的代表性在初级运动colter（4区）的成年松鼠猴之前和几个月后局灶性缺血性梗死。在使用对侧手时，截肢引起了明显但短暂的缺陷，这可以通过增加使用同侧手来证明，并且在需要熟练使用手指的任务中表现降低。结果显示，病灶附近的手指表现的面积范围广泛减少，而邻近的近端表现明显增加.我们的结论是，大量的功能重组发生在成年灵长类动物的初级运动皮层局灶性缺血性梗死后，但至少在没有postinfarction的培训，以前代表的运动在梗死区不重现在相邻的皮质区域。
1. Intracortical microstimulation (ICMS) techniques were used to derive detailed maps of distal forelimb movement representations in primary motor colter (area 4) of adult squirrel monkeys before and a few months after a focal ischemic infarct.2. Infarcts caused a marked but transient deficit in use of the contralateral hand, as evidenced by increased use of the ipsilateral hand, and reduced performance on a task requiring skilled digit use.3. Infarcts resulted in a widespread reduction in the areal extent of digit representations adjacent to the lesion, and apparent increases in adjacent proximal representations.4. We conclude that substantial functional reorganization occurs in primary motor cortex of adult primates following a focal ischemic infarct, but at least in the absence of postinfarct training, the movements formerly represented in the infarcted zone do not reappear in adjacent cortical regions.