Biological studies of post-traumatic stress disorder.
Biological studies of post-traumatic stress disorder.
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DOI：
10.1038/nrn3339
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Liberzon I
中科院分区：
文献类型：
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作者：
Pitman RK;Rasmusson AM;Koenen KC;Shin LM;Orr SP;Gilbertson MW;Milad MR;Liberzon I
创伤后应激障碍（PTSD）是唯一一种被认为是已知原因的主要精神障碍，即，威胁到自己或他人身体完整性并引起强烈恐惧、无助或恐怖反应的事件。虽然PTSD在很大程度上仍然被认为是一种心理现象，但在过去的30年里，生物PTSD文献的增长是爆炸性的，现在有成千上万的参考文献。最终，环境事件的影响，如心理创伤，必须在有机，细胞和分子水平上理解。本审查试图提出目前的状态，这种理解的基础上，在人类和动物模型的心理生理学，结构和功能的神经影像学，内分泌学，遗传学和分子生物学研究。
Posttraumatic stress disorder (PTSD) is the only major mental disorder for which a cause is considered to be known, viz., an event that involves threat to the physical integrity of oneself or others and induces a response of intense fear, helplessness, or horror. Although PTSD is still largely regarded as a psychological phenomenon, over the past three decades the growth of the biological PTSD literature has been explosive, and thousands of references now exist. Ultimately, the impact of an environmental event, such as a psychological trauma, must be understood at organic, cellular, and molecular levels. The present review attempts to present the current state of this understanding, based upon psychophysiological, structural and functional neuroimaging, endocrinological, genetic, and molecular biological studies in humans and in animal models.