An innovative regenerative treatment of scars with dermal micrografts
An innovative regenerative treatment of scars with dermal micrografts
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DOI：
10.1111/jocd.12212
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发表时间：
2016-09-01
影响因子：
2.3
通讯作者：
Ferraro, Giuseppe A.
中科院分区：
文献类型：
--
作者：
Svolacchia, Fabiano;De Francesco, Francesco;Ferraro, Giuseppe A.
背景病理性瘢痕发生在损伤后，通常被认为在美学上不吸引人。已经尝试了几种策略来使用手术和非手术方法来改善这些类型的疤痕。最常见的治疗方法包括冷冻治疗、皮损内注射皮质类固醇、5-氟尿嘧啶、博莱霉素、干扰素和维拉帕米。目的本研究旨在探讨自体真皮移植治疗烧伤、创伤或任何医源性病理性瘢痕的有效性。方法我们使用一种新的临床实践--Rigenera方案来获得自体微型移植物，然后将其注入患者体内。结果经过4个月的自体微型移植物治疗后，所有病例的夸大瘢痕的外观和质地都有明显的改善。我们还证明了这些微型移植物是由间充质干细胞组成的，此外，这些微移植物还包括组织学评估证实了真皮下结构层的修复和乳头状真皮中胶原纤维的水平重排。结论我们的结果清楚地证明了真皮显微移植治疗不同原因的夸张瘢痕取得了最佳的效果。然而，还需要进一步的研究来证实这项新技术的有效性。
Background Pathological scars occur following injuries and are often considered esthetically unattractive. Several strategies have been attempted to improve these types of scars using both surgical and nonsurgical methods. The most common treatments include cryotherapy, intralesional corticosteroid injections, 5-fluorouracil, bleomycin, interferon, and verapamil.Aims In this study, we aim to investigate the effectiveness of dermal autologous micrografts in the treatment of pathological scars resulting from burns, trauma, or any iatrogenic source.Methods We used a new clinical practice called Rigenera Protocol to obtain autologous micrografts which were in turn injectable in the patients.Results A significant improvement was observed in appearance and texture of the exaggerated scars in all cases following already 4 months of autologous micrograft treatment We have also shown that these micrografts are composed of mesenchymal stem cells and in addition, histological evaluation verified restoration of the structural layers immediately below the epidermis and a horizontal realignment of collagen fibers in the papillary dermis.Conclusion Our results clearly demonstrate the optimal outcomes obtained following treatment with dermal micrografts on exaggerated scars with different etiologies. However, further studies are required to confirm the efficacy of this new technique.