Altered brain activation during action imitation and observation in schizophrenia: a translational approach to investigating social dysfunction in schizophrenia.
Altered brain activation during action imitation and observation in schizophrenia: a translational approach to investigating social dysfunction in schizophrenia.
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DOI：
10.1176/appi.ajp.2013.13040498
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Park S
中科院分区：
文献类型：
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作者：
Thakkar KN;Peterman JS;Park S
社会障碍是精神分裂症的一个关键特征，但其潜在机制尚不清楚。模仿是我们理解他人思想的一个过程，它涉及到所谓的镜像神经元系统，这是一个由顶下叶、额下回和后上颞沟组成的网络。作者检测了精神分裂症患者的镜像神经系统功能。16名服药精神分裂症患者和16名健康对照受试者在功能磁共振成像中进行动作模拟/观察任务。参与者观看了一段移动的手或空间线索的视频，并被指示要么执行与刺激相关的手指运动，要么简单地观察。在模仿和非模仿动作，以及观察移动的手和移动的空间线索的过程中，镜像神经元系统的激活被测量。这些对比在不同的组之间进行了比较。在精神分裂症患者中，镜像神经元系统的激活对模仿的特异性较低。与健康受试者相比，患者在模仿时颞后上沟的活动减少，而在非模仿动作时在后上沟和顶下叶的活动增加。在行动观察期间，患者还显示出这些区域的活动减少。镜像神经系统的激活与患者的症状严重程度和社会功能有关，而在对照对象中与分裂型综合征有关。鉴于顶下叶和后上颞沟在模仿和社会认知中的作用，精神分裂症患者的模仿能力受损可能源于对生物运动的错误感知和从感知到行动的转换。这些发现扩展了我们对精神分裂症患者社交功能障碍的理解。
Social impairments are a key feature of schizophrenia, but their underlying mechanisms are poorly understood. Imitation, a process through which we understand the minds of others, involves the so-called mirror neuron system, a network comprising the inferior parietal lobe, inferior frontal gyrus, and posterior superior temporal sulcus. The authors examined mirror neuron system function in schizophrenia. Sixteen medicated schizophrenia patients and 16 healthy comparison subjects performed an action imitation/ observation task during functional MRI. Participants saw a video of a moving hand or spatial cue and were instructed to either execute finger movements associated with the stimulus or simply observe. Activation in the mirror neuron system was measured during imitative versus nonimitative actions and observation of a moving hand versus a moving spatial cue. These contrasts were compared across groups. Activation in the mirror neuron system was less specific for imitation in schizophrenia. Relative to healthy subjects, patients had reduced activity in the posterior superior temporal sulcus during imitation and greater activity in the posterior superior temporal sulcus and inferior parietal lobe during nonimitative action. Patients also showed reduced activity in these regions during action observation. Mirror neuron system activation was related to symptom severity and social functioning in patients and to schizotypal syndrome in comparison subjects. Given the role of the inferior parietal lobe and posterior superior temporal sulcus in imitation and social cognition, impaired imitative ability in schizophrenia may stem from faulty perception of biological motion and transformations from perception to action. These findings extend our understanding of social dysfunction in schizophrenia.