Tiazofurin-induced selective depression of NAD content in hepatoma 3924A.
Tiazofurin-induced selective depression of NAD content in hepatoma 3924A.
复制标题
噻唑呋林诱导肝癌 3924A 中 NAD 含量的选择性降低。
DOI：
10.1016/0006-291x(84)90481-9
复制
发表时间：
1984
影响因子：
3.1
通讯作者：
Weber,G
中科院分区：
文献类型：
--
作者：
Liepnieks,JJ;Faderan,MA;Lui,MS;Weber,G
3924A肝癌中NAD含量约为ACI-N大鼠肝脏NAD含量的40%。用噻唑呋喃治疗荷瘤大鼠，可减少肝癌组织中NAD池，但对肝脏无明显影响。在剂量-反应研究中，注射不同数量的药物以剂量依赖的方式减少了肝癌中的NAD池。在时间序列研究中，单次给药剂量(200 mg/kg)在给药后2~24小时内使肝癌NAD池减少到对照组的50%左右，48小时后恢复到对照组的50%左右，该药的抗癌作用和毒性可能与该药的抗癌作用和毒性有关。
The NAD content in hepatoma 3924A was approximately 40% of that in the liver of ACI N rats bearing this hepatoma. Treatment of tumor-bearing rats with tiazofurin decreased NAD pools in the hepatoma, but no change was apparent in the liver. In a dose-response study, injection of varying amounts of the drug decreased NAD pools in the hepatoma in a dose-dependent fashion. In time-sequence studies, a single drug dose (200 mg/kg) depressed NAD pools in the hepatoma from 2 to 24 h after injection to approximately 50% of control at the lowest point before returning to control range at 48 h. The tiazofurin-induced depletion of NAD pools in the hepatoma to approximately 20% of that of normal liver might play a role in the anti-cancer action and toxicity of this drug.