Homologs of eleven loci on human chromosome 11 assigned to two owl monkey chromosomes.
Homologs of eleven loci on human chromosome 11 assigned to two owl monkey chromosomes.
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人类 11 号染色体上的 11 个基因座的同源物分配给两条猫头鹰猴染色体。
DOI：
10.1159/000133090
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Bock,SC
中科院分区：
文献类型：
--
作者：
Ma,NS;Gerhard,DS;Bock,SC
利用体细胞杂交技术，我们将人类11号染色体上的11个基因座定位于枭猴核型VI（2n = 49/50）的4号和19号染色体上。此外，使用原位杂交两个猫头鹰猴核型的染色体，HSTF 1癌基因位点被精确定位在同源19 q（K-VI）和2 q（K-11）。比较分析人类、小鼠和猫头鹰猴染色体之间的基因图谱数据，揭示了人类11号染色体上同线组的进化变化模式。这些结构变化可以解释为在灵长类进化过程中，人类染色体11 cen →q13区域的臂间倒位和涉及人类11 q22 →qter区域的易位。
We localized 11 loci mapped to human chromosome 11 to two chromosomes, 4 and 19 of owl monkey karyotype VI (2n = 49/50), by the use of somatic cell hybrids. Furthermore, using in situ hybridization to chromosomes of two owl monkey karyotypes, the HSTF1 oncogene locus was precisely localized on homologs 19q (K-VI) and 2q (K-11). Comparative analysis of available gene-mapping data among human, mouse, and owl monkey chromosomes revealed a pattern of evolutionary change in a syntenic group on human chromosome 11. These structural changes could be explained as having derived from a pericentric inversion of human chromosome region 11cen→q13 and a translocation involving human region 11q22→qter during primate evolution.