Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: A large population-based prospective cohort study
Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: A large population-based prospective cohort study
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DOI：
10.1016/j.clnu.2017.02.010
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发表时间：
2018-04-01
影响因子：
6.3
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Eshak, Ehab S.;Iso, Hiroyasu;Tamakoshi, Akiko
背景与目的：铁、铜、锌稳态异常是2型糖尿病（T2 DM）的发病机制之一。然而，这些元素的饮食摄入量和T2 DM之间的关联的证据是有限的。我们想研究日本人群铁、铜和锌的膳食摄入量与T2 DM风险之间的关系。一项前瞻性研究，包括16,160名年龄在40-65岁之间的健康日本男性和女性，其中通过经验证的自我管理食物频率问卷确定铁、铜和锌的饮食摄入量之间的关联，结果：我们确定了396例5年内自我报告的新发糖尿病病例。膳食铁（总铁和非血红素铁，但不含血红素铁）和铜的摄入量与T2 DM的风险呈正相关;摄入量最高与最低四分位数的多变量OR分别为1.32（1.04，1.70; P趋势= 0.03）和1.55（1.13，2.02; P趋势= 0.003）。这些关联在高危人群中更为明显;老年人，超重，吸烟者和有糖尿病家族史的人。膳食锌摄入量与T2 DM风险呈负相关，多变量OR为0.64（0.54，1.00; P趋势= 0.003），这种关联在年轻受试者中很明显（40-55岁）。铁和铜的饮食摄入量与更高的风险有关，而膳食锌摄入量与日本人群T2 DM风险降低相关。(C)2017 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Abnormal homeostasis of iron, copper and zinc has been included in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the evidence of associations between dietary intakes of these elements and T2DM is limited. We thought to examine the association between dietary intakes of iron, copper and zinc with risk of T2DM in Japanese population.Methods: A prospective study encompassing 16,160 healthy Japanese men and women aged 40-65 years in whom the associations between dietary intakes of iron, copper and zinc, determined by a validated self-administered food frequency questionnaire, with risk of 5-year cumulative incidence of validated physician-diagnosed T2DM, were evaluated by logistic regression model.Results: We ascertained 396 self-reported new cases of diabetes within 5-year period. Dietary intakes of iron (total and nonheme but not heme iron) and copper were positively associated with risk of T2DM; the multivariable OR in the highest versus lowest quartiles of intakes were 1.32 (1.04, 1.70; P-trend = 0.03) and 1.55 (1.13, 2.02; P-trend = 0.003), respectively. These associations were more evident in the high risk group; older, overweight, smokers and those with family history of diabetes. The dietary intake of zinc was inversely associated with risk of T2DM; the multivariable OR was 0.64 (0.54, 1.00; P-trend = 0.003), and such association was evident among younger subjects (age 40-55 years) only.Conclusions: Dietary intakes of iron and copper were associated with a higher risk, while dietary intake of zinc was associated with a reduced risk of T2DM in Japanese population. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.