Pesticides and risk of Parkinson disease a population-based case-control study
Pesticides and risk of Parkinson disease a population-based case-control study
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DOI：
10.1001/archneur.62.1.91
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发表时间：
2005-01-01
影响因子：
--
通讯作者：
Checkoway, H
中科院分区：
文献类型：
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作者：
Firestone, JA;Smith-Weller, T;Checkoway, H
背景资料：农药暴露是帕金森病（PD）的可疑危险因素，但流行病学A服务一直不一致。目的：调查农药暴露和特发性PD之间的关联。设计：基于人群的病例对照研究。设置：团体健康合作社，华盛顿州西部的一个卫生保健系统，和华盛顿大学。参与者：250例偶发PD病例患者和388例健康受试者）、对照受试者（年龄和性别匹配）。我们评估了自我报告的农药暴露使用结构化的inter-view。结果：职业暴露的优势比不显著，但提示职业暴露的优势比梯度（农药工人OR，2.07：95%CI：0.67 - 6.38;农作物农民OR，2.07：95%CI：0.67- 6.38），职业暴露的优势比（OR，2.07：95%CI：0.67-6.38），职业暴露的优势比（OR，2.07：95%CI：0.67-6.38），职业暴露的优势比（OR，2.07：95%CI：0.67 - 6.38）。1.65; 95% CI，0.84 - 3.27;畜牧业和种植业农民。OR为1.10; 95%CI为0.60-2.00;奶牛场主OR为0.88; 95%CI为0.46-1.70）。有机磷的比值比符合世界卫生组织的危险分类。其中二嗪磷比二嗪磷或马拉硫磷高得多。我们还发现除草剂（OR，1.41; 95%CI，0.51-3.88）和百草枯（OR，1.67; 95%CI，0.22-12-76）的OR升高。我们没有发现家庭接触农药存在风险的证据。我们发现，从终身井水消费量（OR，1.81; 95%CI，1.02-3.21）的OR显着增加。结论：职业农药暴露的调查结果是一致的，越来越多的信息联系农药暴露与PD。但是，缺乏重要的关联。与家庭接触无关联，与农村接触弱关联，表明农药在这一人群中没有发挥重要的病因作用。0
Background: Pesticide exposures are suspected risk factors for Parkinson disease (PD), but epidemiological A servations have been inconsistent.Objective: To investigate associations between pesticide exposures and idiopathic PD.Design: Population-based case-control study.Setting: Group Health Cooperative, a health care system in western Washington State, and the University of Washington.Participants: Two hundred fifty incident PD case patients and 388 health), control subjects (age- and sex-matched). We assessed self-reported pesticide exposures using a structured inter-view. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined using logistic regression models, controlling for age, sex, and smoking.Results: Odds ratios for occupational exposures were not significant but suggested a gradient that paralleled occupational exposures (pesticide worker OR, 2.07: 95% CI: 0.67-6.38; cropfanner: OR., 1.65; 95% CI, 0 84 -3.27; animal and crop farmer. OR, 1.10; 95% CI, 0.60-2.00; and dairy farmer: OR, 0.88; 95% CI, 0.46-1.70). Odds ratios for organophosphates paralleled the World Health Organization hazard classifications. with parathion much higher than diazinon or malathion. We also found elevated ORs from herbicides (OR, 1.41; 95% CI, 0.51-3.88) and paraquat (OR, 1.67; 95% CI, 0.22-12-76). We found no evidence of risk from home-based pesticide exposures. We found significantly increased ORs from life-long well water consumption (OR, 1.81; 95% CI, 1.02-3.21).Conclusions: The findings for occupational pesticide exposures are consistent with a growing body of information linking pesticide exposures with PD. However, the lack of significant associations. absence of associations with home-based exposures, and weak associations with rural exposures suggest that pesticides did not play a substantial etiologic role in this population. 0