Predictive Independent Factors for Extrahepatic Metastasis of Hepatocellular Carcinoma Following Curative Hepatectomy
Predictive Independent Factors for Extrahepatic Metastasis of Hepatocellular Carcinoma Following Curative Hepatectomy
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DOI：
10.21873/anticanres.11609
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发表时间：
2017-05-01
影响因子：
2
通讯作者：
Ohdan, Hideki
中科院分区：
文献类型：
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作者：
Hashimoto, Masakazu;Kobayashi, Tsuyoshi;Ohdan, Hideki
目的：本研究旨在探讨原发性肝细胞癌（HCC）肝外转移的预后因素。患者和方法：我们回顾性分析了559例接受根治性肝切除术的HCC患者。我们将患者分为无复发（NoR）、肝内早期复发（IHER）、肝内晚期复发（IHER）和肝外复发（EHR）组。我们将非转移组（IHER和NoR）与转移组（IHER和EHR）进行了比较，并将IHER与EHR进行了比较，以确定EHR的风险因素。结果：分别有252、163、109和35例患者出现NoR、IHER、IHR和EHR。对于EHR组，独立的危险因素是血管侵犯。EHR组肝功能较好，肿瘤因子较差。结论：血管侵犯是肝癌肝外转移的预测指标。
Aim: The aim of this study was to investigate the prognostic factors associated with extrahepatic metastasis of primary hepatocellular carcinoma (HCC). Patients and Methods: We retrospectively analyzed 559 patients with HCC who underwent curative hepatectomy. We divided the patients into no recurrence (NoR), intrahepatic early recurrence (IHER), intrahepatic late recurrence (IHLR), and extrahepatic recurrence (EHR) groups. We compared the non-metastatic group (IHLR and NoR) with the metastatic group (IHER and EHR) and also compared IHER with EHR to determine risk factors for EHR. Results: There were 252, 163, 109, and 35 patients with NoR, IHER, IHLR, and EHR, respectively. For the EHR group, the independent risk factor was vascular invasion. The EHR group had better liver function and worse tumor factors. Conclusion: Vascular invasion is predictive of extrahepatic metastasis of HCC.