Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial.
Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial.
复制标题
低剂量脱氢表雄酮影响垂体雄激素缺乏女性的行为：一项安慰剂对照试验。
DOI：
10.1210/jcem.87.5.8494
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
F. Karlsson
中科院分区：
文献类型：
--
作者：
G. Johannsson;P. Burman;L. Wíren;B. Engström;Anna G. Nilsson;M. Ottosson;B. Jonsson;B. Bengtsson;F. Karlsson
38名年龄在25-65岁的垂体功能减退症所致雄激素缺乏的妇女<45 yr of age and 20 mg if >在一项随机、安慰剂对照、双盲研究中接受口服脱氢表雄酮（DHEA;如果年龄≥ 45岁，30 mg/d）治疗6个月，随后是6个月的开放治疗期。DHEA的管理提高了血清DHEAS水平正常年龄相关的参考范围和增加雄烯二酮和T低于正常水平。在所有接受DHEA治疗6个月后，84%（32/38）的女性观察到雄激素对皮肤和/或阴毛和/或腋毛的影响。安慰剂治疗后未观察到此类效应。6个月后的这些效应与血清DHEAS（r = 0.37; P = 0.03）、雄烯二酮（r = 0.42; P = 0.01）和T（r = 0.37; P = 0.03）水平相关。在DHEA组中，配偶报告其警觉性、耐力和主动性得到改善的伴侣比例分别为70%、64%和55%，而安慰剂组分别为11%、6%和11%（P < 0.05）。根据伴侣的说法，与安慰剂相比，性关系倾向于改善（P = 0.06）。治疗6个月后，服用30 mg DHEA的女性中有50%报告性兴趣或性活动增加，服用20 mg DHEA的女性中没有人报告性兴趣或性活动增加，服用安慰剂的女性中有2人报告性兴趣或性活动增加（P = NS）。与安慰剂给药后的水平相比，DHEA后高密度脂蛋白胆固醇和载脂蛋白A-1水平降低。血清IGF-I浓度、骨代谢血清标志物和骨密度均无变化。总之，口服低剂量DHEA的成年hypopolysis妇女诱导雄激素对皮肤和腋毛和阴毛的影响，以及行为的变化，只有轻微的影响代谢。
Thirty-eight women, aged 25-65 yr, with androgen deficiency due to hypopituitarism were treated with oral dehydroepiandrosterone (DHEA; 30 mg/d if <45 yr of age and 20 mg if > or =45 yr of age) for 6 months in a randomized, placebo-controlled, double blind study, followed by a 6-month open treatment period. The administration of DHEA raised the serum levels of DHEAS to normal age-related reference ranges and increased androstenedione and T to subnormal levels. Androgen effects on skin and/or pubic and/or axillary hair were observed in 84% (32 of 38) of the women after all received 6 months of DHEA treatment. No such effects were observed after the placebo treatment. These effects after 6 months were correlated with the serum levels of DHEAS (r = 0.37; P = 0.03), androstenedione (r = 0.42; P = 0.01), and T (r = 0.37; P = 0.03). The percentages of partners who reported improved alertness, stamina, and initiative by their spouses were 70%, 64%, and 55%, respectively, in the DHEA group and 11%, 6%, and 11%, respectively, in the placebo group (P < 0.05). According to the partners, sexual relations tended to improve compared with placebo (P = 0.06). After 6 months of treatment, increased sexual interest or activity was reported by 50% of the women taking 30 mg DHEA, by none taking 20 mg DHEA, and by two women taking placebo (P = NS). Compared with levels after placebo administration, high density lipoprotein cholesterol and apolipoprotein A-1 levels decreased after DHEA. Serum concentrations of IGF-I, serum markers of bone metabolism, and bone density did not change. In conclusion, oral administration of a low dose of DHEA to adult hypopituitary women induced androgen effects on skin and axillary and pubic hair as well as changes in behavior, with only minor effects on metabolism.
患有垂体机能减退症的女性雄激素缺乏。
DOI：
10.1210/jcem.86.2.7246
发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Miller,KK;Sesmilo,G;Schiller,A;Schoenfeld,D;Burton,S;Klibanski,A
通讯作者：
Klibanski,A
DOI：
10.1097/00006254-200004000-00020
发表时间：
2000-04
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
K. Barnhart;E. Freeman;J. A. Grisso;D. Rader;M. Sammel;S. Kapoor;J. Nestler
通讯作者：
K. Barnhart;E. Freeman;J. A. Grisso;D. Rader;M. Sammel;S. Kapoor;J. Nestler