Blood compatibility of surfaces modified by plasma polymerization.
Blood compatibility of surfaces modified by plasma polymerization.
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通过等离子体聚合改性的表面的血液相容性。
DOI：
10.1002/jbm.820220904
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Yasuda,H
中科院分区：
文献类型：
--
作者：
Yeh,YS;Iriyama,Y;Matsuzawa,Y;Hanson,SR;Yasuda,H
管状与血液接触的聚合物材料通过血浆聚合进行了改性，并在狒狒身上评估了它们诱导急性和慢性动脉血栓形成的能力。用电子能谱进行化学分析，测定了聚合物的表面组成。稳态动脉血栓栓塞症是通过将管状节段引入慢性动静脉分流术而开始的。通过对111例血小板内存活率的测量，计算了受试材料诱导的血小板破坏率。基于四氟乙烯、六氟乙烷、六氟乙烷/氢和甲烷的九种等离子体聚合物，当沉积在硅橡胶上时，以1.1-5.6×108个/cm2-天的速率消耗血小板。由于这些值接近该测试系统的检测下限，因此血浆聚合物被认为相对不会导致血栓形成。将扩张的聚四氟乙烯(Gore-Tex PTFE)血管植入分流系统，引发急性血栓形成。111In-血小板沉积通过闪烁相机成像在1h的曝光期内测量。标准聚四氟乙烯移植物(10厘米×4毫米直径)在这段时间内，累积了大约1×1010个血小板。虽然以六氟乙烷/氢为基础的等离子体聚合物修饰聚四氟乙烯接枝并没有改变移植物表面的形态，但与对照组相比，血小板沉积减少了87%(p<；0.001)。我们得出结论，假体材料的表面化学成分和质地都会影响血栓的形成。血浆聚合的方法可能有助于独立评估这些变量的重要性，也许还有助于最小化某些不利的血液-材料相互作用。
Tubular blood‐contacting polymeric materials were modified by plasma polymerization and evaluated in the baboon with respect to their capacity to induce both acute and chronic arterial thrombosis. Polymer surface composition was determined by electron spectroscopy for chemical analysis. Steady‐state arterial thromboembolism was initiated by introducing tubular segments into chronic arteriovenous shunts. Rates of platelet destruction induced by the test materials were calculated from111In‐platelet survival measurements. Nine plasma polymers based on tetrafluoroethylene, hexafluoroethane, hexafluoroethane/H2, and methane, when deposited on silicone rubber, consumed platelets at rates ranging from 1.1–5.6 × 108platelets/cm2‐day. Since these values were near the lower detection limit for this test system, the plasma polymers were considered relatively nonthrombogenic. Acute thrombus formation was initiated by inserting expanded Teflon (Gore‐Tex PTFE) vascular grafts into the shunt system.111In‐platelet deposition was measured by scintillation camera imaging over a 1‐h exposure period. Standard PTFE grafts (10 cm × 4 mm i. d.) accumulated approximately 1 × 1010platelets over this interval. While modification of PTFE grafts with a plasma polymer based on hexafluoroethane/H2did not alter graft surface morphology, platelet deposition was reduced by 87% as compared to the controls (p< 0.001). We conclude that both the surface chemistry and texture of prosthetic materials influence thrombogenesis. The method of plasma polymerization may be useful for assessing the importance of these variables independently and, perhaps, for minimizing certain adverse blood–material interactions.