Current topics of organic and biological chemistry of annonaceous acetogenins and their synthetic mimics.
Current topics of organic and biological chemistry of annonaceous acetogenins and their synthetic mimics.
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番荔枝苷及其合成模拟物的有机和生物化学的当前主题。
DOI：
10.2174/157016308785739820
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发表时间：
2008
影响因子：
--
通讯作者：
H. Miyoshi
中科院分区：
文献类型：
--
作者：
H. Makabe;H. Konno;H. Miyoshi
番荔枝内酯是天然聚酮化合物的大家族。到目前为止，已经分离出430多个化合物。在生物学上，它们是线粒体电子传递系统中最有效的复合物I（NADH-泛醌氧化还原酶）抑制剂之一。本文就配合物I的全合成、结构修饰、抑制作用构效关系及作用机制等方面的研究进展进行综述。
Annonaceous acetogenins are a large family of natural polyketides. So far, more than 430 compounds have been isolated. Biologically, they are among the most potent of the known inhibitors of complex I (NADH-ubiquinone oxidoreductase) in mitochondrial electron transfer system. Herein, we would like to conduct an overview on the progress of the total synthesis, structural revisions, structure activity relationship for the inhibition of complex I, and action mechanism.