Clinical Observation of Choroidal Osteoma Using Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography
Clinical Observation of Choroidal Osteoma Using Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography
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DOI：
10.3390/app12094472
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发表时间：
2022-05-01
影响因子：
2.7
通讯作者：
Wang, Min
中科院分区：
文献类型：
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作者：
Xuan, Yi;Chang, Qing;Wang, Min
继发于脉络膜骨瘤（CO）的脉络膜新生血管（CNV）可导致严重的视力丧失，但使用传统的荧光血管造影成像检测CNV和肿瘤的供血血管是具有挑战性的。新开发的TowardPi扫频源光学相干断层扫描（SS-OCT）和OCT血管造影（SS-OCTA）可实现超高分辨率、更长波长（1060 nm）的增强穿透、快速扫描速率（400 KHz）、随深度增加而减少的信号强度损失以及120度角宽视野眼底视图，从而实现视网膜和脉络膜的近乎组织学描述。因此，我们使用该SS-OCT和SS-OCTA平台来观察21例患者的23只眼睛的骨瘤的内在特征。结果发现，CO的边界清楚地从相邻的脉络膜Sattler和Haller层划分，而在相应的B扫描上，CO的血流主要在脉络膜帽内检测到，部分在Sattler层内。CNV是由许多分支或放射状血管与固有的滋养血管连接而成，表现出各种形态，包括人参、方便面、生长环、缠结、蜘蛛网、水母、海帆和不规则形状。此外，发现肿瘤样组织生长在破坏的布鲁赫膜上方。SS-OCTA可用于CO肿瘤血管的检测。
Choroidal neovascularization (CNV) secondary to choroidal osteoma (CO) can cause profound visual loss, but detecting CNV and the tumor's feeder vessels using traditional fluorescent angiography imaging is challenging. Newly developed TowardPi swept-source optical coherence tomography (SS-OCT) and OCT angiography (SS-OCTA) enable ultra-high resolution, enhanced penetration with longer wavelength (1060 nm), a rapid scan rate (400 KHz), reduced loss of signal strength with increasing depth, and 120 degrees angular widefield of fundus view, enabling a nearly histological description of the retina and choroid. We therefore used this SS-OCT and SS-OCTA platform to observe the intrinsic features of osteoma in 23 eyes of 21 patients. It was found that the borders of CO were clearly demarcated from the adjacent choroidal Sattler's and Haller's layers, while on a corresponding B-scan the blood flow of the CO was detected mainly within the choriocapillaries and partly within Sattler's layer. The CNV was identified as numerous branching or radiating vessels connecting with intrinsic feeder vessels displaying various patterns including ginseng, instant noodle, growth ring, tangle, spider web, medusa, seafan, and irregular shape. Moreover, tumor-like tissues were found to grow above the disrupted Bruch's membrane. SS-OCTA can be used to detect the tumor vasculature in CO.