Narcotics and Sedative Use in Preterm Neonates
Narcotics and Sedative Use in Preterm Neonates
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DOI：
10.1016/j.jpeds.2016.08.031
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发表时间：
2017-01-01
影响因子：
5.1
通讯作者：
Shah, Prakesh S.
中科院分区：
文献类型：
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作者：
Borenstein-Levin, Iron;Synnes, Anne;Shah, Prakesh S.
ObjectiveTo evaluate patterns of anesthesia and sedative use in neonatal intensive care units（NICU）across Canada using data collected by the Canadian Neonatal Network.Study design我们对妊娠< 33周的早产儿进行了一项回顾性观察队列研究，这些早产儿入住加拿大新生儿网络NICU。计算每年在NICU住院期间接受镇静剂、麻醉剂或镇静剂、麻醉剂或两者的所有新生儿的比例。由于阿片类药物用于插管前的术前用药，因此仅包括麻醉药物的连续输注。使用logistic回归分析确定2014年各研究中心麻醉剂和镇静剂使用情况的变化，并对胎龄、手术和机械通气进行调整。结果在20 744名新生儿中，29%的新生儿接受麻醉剂、镇静剂或两者兼而有之; 23%接受麻醉剂，17%接受镇静剂。虽然在5年期间没有记录到药物暴露的临床显著变化，但不同地点之间麻醉剂和镇静剂使用的统计学显著差异，麻醉剂使用的范围为3%-41%，镇静剂使用的范围为2%-48%（aOR分别为0.2-5.7和0.1-15，P
Objectives To evaluate patterns of narcotic and sedative use in neonatal intensive care units (NICUs) across Canada using data collected by the Canadian Neonatal Network.Study design We conducted a retrospective observational cohort study of preterm neonates at < 33 weeks' gestation and admitted to a participating Canadian Neonatal Network NICU. The proportion of all neonates who received sedative(s), narcotic(s), or either sedative(s), narcotic(s), or both during their NICU stay was calculated for each year. Because opioids are used for premedication before intubation, only continuous infusions of a narcotic drug were included. Variation in narcotics and sedative usage between sites in 2014 was determined using logistic regression analysis, with adjustment for gestational age, surgery, and mechanical ventilation.Results Of 20 744 neonates, 29% of neonates received a narcotic, a sedative, or both; 23% received a narcotic and 17% a sedative. Although no clinically significant changes in drug exposure were documented during the 5-year period, there were statistically significant differences in narcotic and sedative use between sites, ranging from 3% to 41% for narcotic and 2% to 48% for sedative use (aORs 0.2-5.7 and 0.1-15, respectively, P