A Comparative Biocompatibility Analysis of Ternary Nitinol Alloys
A Comparative Biocompatibility Analysis of Ternary Nitinol Alloys
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DOI：
10.1007/s11665-009-9435-5
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发表时间：
2009-08-01
影响因子：
2.3
通讯作者：
Amruthaluri, Sushma
中科院分区：
文献类型：
--
作者：
Haider, Waseem;Munroe, Norman;Amruthaluri, Sushma
镍钛合金在医疗行业的各种应用中正迅速被用作材料的选择。它已被用于自膨胀支架、移植物支持系统和各种其他微创介入和内窥镜手术设备。然而，由于许多患者对镍敏感，这种合金的生物相容性仍然是该行业许多从业者的担忧。最近，随着三元元素的加入，几种新的镍钛合金被引入。然而，关于这些合金的生物相容性和耐腐蚀性的信息仍然很匮乏。本研究比较了粉末冶金(PM)和电弧熔炼(AM)制备的两种三元镍钛合金的生物相容性，并对三元元素的影响进行了评价。采用ASTM F 2129-08体外循环极化腐蚀试验评价其在磷酸盐缓冲盐水(PBS)中的耐蚀性。光学显微镜下观察内皮细胞在NiTi表面的生长情况。
Nitinol alloys are rapidly being utilized as the material of choice in a variety of applications in the medical industry. It has been used for self-expanding stents, graft support systems, and various other devices for minimally invasive interventional and endoscopic procedures. However, the biocompatibility of this alloy remains a concern to many practitioners in the industry due to nickel sensitivity experienced by many patients. In recent times, several new Nitinol alloys have been introduced with the addition of a ternary element. Nevertheless, there is still a dearth of information concerning the biocompatibility and corrosion resistance of these alloys. This study compared the biocompatibility of two ternary Nitinol alloys prepared by powder metallurgy (PM) and arc melting (AM) and critically assessed the influence of the ternary element. ASTM F 2129-08 cyclic polarization in vitro corrosion tests were conducted to evaluate the corrosion resistance in phosphate buffered saline (PBS). The growth of endothelial cells on NiTi was examined using optical microscopy.