NSAIDs and breast cancer recurrence in a prospective cohort study
NSAIDs and breast cancer recurrence in a prospective cohort study
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DOI：
10.1007/s10552-007-9003-y
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发表时间：
2007-08-01
影响因子：
2.3
通讯作者：
Caan, Bette
中科院分区：
文献类型：
--
作者：
Kwan, Marilyn L.;Habel, Laurel A.;Caan, Bette
目的：我们对 1997 年至 2000 年诊断出的 2,292 名早期乳腺癌幸存者参加了癌症流行病学 (LACE) 研究后的前瞻性队列，研究了 NSAID 使用与乳腺癌复发之间的关联。方法：从 2000 年到 2002 年，使用邮寄问卷来获取有关阿司匹林、布洛芬和其他 NSAID 使用以及随后乳腺癌事件的信息。共有 270 例复发病例（局部、区域和远处疾病以及新的原发性乳腺癌）被报告并经病历审查核实。使用 Cox 比例风险模型来估计率比 (RR) 和 95% 置信区间 (CI)，调整诊断时的年龄、种族、癌症分期、他莫昔芬治疗、化疗使用、体重指数和环加氧酶 2 (COX2) 抑制剂的使用。结果：目前定期使用布洛芬（RR、问卷时每周至少三天） 0.56； 95% CI，0.32-0.98），但阿司匹林（RR，1.09；95% CI，0.74-1.61）与乳腺癌复发风险统计显着降低相关。布洛芬与其他非阿司匹林非甾体抗炎药（例如萘普生和舒林酸）的组合反映了类似的风险降低（RR，0.56；95％CI，0.33-0.95）。未发现非 NSAID 镇痛药对乙酰氨基酚之间存在关联。结论：我们的研究结果支持当前定期使用布洛芬与乳腺癌复发之间存在负相关关系。
Objective: We examined the association between NSAID use and breast cancer recurrence in a prospective cohort of 2,292 early-stage breast cancer survivors diagnosed from 1997 to 2000 participating in the Life After Cancer Epidemiology (LACE) Study.Methods: From 2000 to 2002, mailed questionnaires were used to obtain information on aspirin, ibuprofen, and other NSAID use and subsequent breast cancer events. A total of 270 recurrences (local, regional, and distant disease and new primary breast cancers) were reported and verified by medical record review. Cox proportional hazard models were used to estimate rate ratios (RR) and 95% confidence intervals (CI), adjusting for age at diagnosis, race, cancer stage, tamoxifen treatment, chemotherapy use, body mass index, and cyclooxygenase-2 (COX2) inhibitor use.Results: Current, regular use (at least three days per week at time of questionnaire administration) of ibuprofen (RR, 0.56; 95% CI, 0.32-0.98), but not aspirin (RR, 1.09; 95% CI, 0.74-1.61), was associated with a statistically significant decreased risk of breast cancer recurrence. The combination of ibuprofen and other non-aspirin NSAIDs such as naproxen and sulindac reflected a similar reduction in risk (RR, 0.56; 95% CI, 0.33-0.95). No association was found for the non-NSAID analgesic acetaminophen.Conclusion: Our findings provide support for an inverse association between current, regular ibuprofen use and breast cancer recurrence.