Current and future biomarkers in the treatment of colorectal cancer
Current and future biomarkers in the treatment of colorectal cancer
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DOI：
10.1080/17843286.2016.1262996
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发表时间：
2017-01-01
影响因子：
1.6
通讯作者：
Prenen, Hans
中科院分区：
文献类型：
--
作者：
Cuyle, Pieter-Jan;Prenen, Hans
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. CRC develops as a consequence of genomic instability, characterized by various genetic and epigenetic alterations. Its molecular heterogeneity explains the large variability in patient prognosis and treatment response, emphasizing the need for development of accurate prognostic and predictive biomarkers. This article delineates the different pathways of colorectal carcinogenesis and its molecular subtype classification. With this review, we aim to provide a comprehensive overview of the current and future biomarkers guiding clinical decision-making and CRC treatment.
